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Submit ReviewPJ 34 hydrochloride
Description: Potent PARP inhibitor
Chemical Name: N-(5,6-Dihydro-6-oxo-2-phenanthridinyl)-2-acetamide hydrochloride
Purity: ≥98% (HPLC)
Biological Activity for PJ 34 hydrochloride
PJ 34 hydrochloride is a potent inhibitor of poly(ADP-ribose) polymerase (PARP) (EC50 = 20 nM). ~1000-fold more potent than 3-Aminobenzamide (Cat. No. 0788). Protects primary neuronal cells from oxygen-glucose deprivation in vitro and reduces infarct size following focal cerebral ischemia in vivo. Displays protective effects against cisplatin-induced kidney injury. Also displays activity at Pim-1 and Pim-2 kinases at higher concentrations (IC50 values are 3.7 and 16 μM respectively).
Compound Libraries for PJ 34 hydrochloride
PJ 34 hydrochloride is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Epigenetics Library. Find out more about compound libraries available from Tocris.
Technical Data for PJ 34 hydrochloride
| M. Wt | 331.8 |
| Formula | C17H17N3O2.HCl |
| Storage | Desiccate at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 344458-15-7 |
| PubChem ID | 16760621 |
| InChI Key | RURAZZMDMNRXMI-UHFFFAOYSA-N |
| Smiles | Cl.CN(C)CC(=O)NC1=CC2=C(NC(=O)C3=CC=CC=C23)C=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for PJ 34 hydrochloride
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 33.18 | 100 | |
| DMSO | 33.18 | 100 |
Preparing Stock Solutions for PJ 34 hydrochloride
The following data is based on the product molecular weight 331.8. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.01 mL | 15.07 mL | 30.14 mL |
| 5 mM | 0.6 mL | 3.01 mL | 6.03 mL |
| 10 mM | 0.3 mL | 1.51 mL | 3.01 mL |
| 50 mM | 0.06 mL | 0.3 mL | 0.6 mL |
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Product Datasheets for PJ 34 hydrochloride
References for PJ 34 hydrochloride
References are publications that support the biological activity of the product.
Abdelkarim et al (2001) Protective effects of PJ34, a novel, potent inhibitor of poly(ADP-ribose) polymerase (PARP) in in vitro and in vivo models of stroke. Int.J.Mol.Med. 7 255 PMID: 11179503
Gambi et al (2008) Poly(ADPR)polymerase inhibition and apoptosis induction in cDDP-treated human carcinoma cell lines. Biochem.Pharmacol. 75 2356 PMID: 18468580
Kim et al (2012) Poly(ADP-ribose) polymerase 1 activation is required for cisp. nephrotoxicity. Kidney Int. 82 193 PMID: 22437413
Antolin et al (2012) Identification of Pim kinases as novel targets for PJ34 with confounding effects in PARP biology. ACS Chem.Biol. 7 1962 PMID: 23025350
If you know of a relevant reference for PJ 34 hydrochloride, please let us know.
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Keywords: PJ 34 hydrochloride, PJ 34 hydrochloride supplier, Potent, PARP, inhibitors, inhibits, PolyADP-ribose, Polymerases, PJ34, hydrochloride, Poly(ADP-ribose), Polymerase, 3255, Tocris Bioscience
1 Citation for PJ 34 hydrochloride
Citations are publications that use Tocris products. Selected citations for PJ 34 hydrochloride include:
Kirby et al (2012) Structure of human tankyrase 1 in complex with small-molecule inhibitors PJ34 and XAV939. Acta Crystallogr Sect F Struct Biol Cryst Commun 68 115 PMID: 22297980
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