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PK 44 phosphate

Cat. No. 4145 Submit a Review Datasheet / COA / SDS

Discontinued Product

4145 has been discontinued.

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Description: Potent and selective dipeptidyl peptidase IV (DPP-IV) inhibitor
Chemical Name: (3R)-3-Amino-4-(6,7-difluoro-1H-indazol-3-yl)-1-[5,6-dihydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazin-7(8H)-yl]-1-butanone phosphate
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Biological Activity Technical Data Datasheets References

Biological Activity for PK 44 phosphate

PK 44 phosphate is a potent inhibitor of dipeptidyl peptidase IV (DPP-IV) (IC50 = 15.8 nM). Displays >1000-fold selectivity for DPP-IV over DPP-8 and DPP-9. Improves glucose tolerance in a mouse oral glucose tolerance assay.

Technical Data for PK 44 phosphate

M. Wt 527.34
Formula C17H16F5N7O.H3PO4
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1017682-66-4
PubChem ID 90488917
InChI Key IRIGBESJZBGJOS-DDWIOCJRSA-N
Smiles N[C@@H](CC(N4CC3=NN=C(C(F)(F)F)N3CC4)=O)CC2=NNC1=C(F)C(F)=CC=C12.OP(O)(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for PK 44 phosphate

Certificate of Analysis / Product Datasheet
Safety Datasheet

References for PK 44 phosphate

References are publications that support the biological activity of the product.

Tozer et al (2010) Indole- and indazole-based inhibitors of dipeptidyl peptidase IV for the treatment of type 2 diabetes. 32nd Annual National Medicinal Chemistry Symposium Poster 52

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Citations for PK 44 phosphate

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