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Description: Potent and selective dipeptidyl peptidase IV (DPP-IV) inhibitor
Chemical Name: (3R)-3-Amino-4-(6,7-difluoro-1H-indazol-3-yl)-1-[5,6-dihydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazin-7(8H)-yl]-1-butanone phosphate
Purity: ≥98% (HPLC)
Biological Activity for PK 44 phosphate
PK 44 phosphate is a potent inhibitor of dipeptidyl peptidase IV (DPP-IV) (IC50 = 15.8 nM). Displays >1000-fold selectivity for DPP-IV over DPP-8 and DPP-9. Improves glucose tolerance in a mouse oral glucose tolerance assay.
Technical Data for PK 44 phosphate
| M. Wt | 527.34 |
| Formula | C17H16F5N7O.H3PO4 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1017682-66-4 |
| PubChem ID | 90488917 |
| InChI Key | IRIGBESJZBGJOS-DDWIOCJRSA-N |
| Smiles | N[C@@H](CC(N4CC3=NN=C(C(F)(F)F)N3CC4)=O)CC2=NNC1=C(F)C(F)=CC=C12.OP(O)(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for PK 44 phosphate
References for PK 44 phosphate
References are publications that support the biological activity of the product.
Tozer et al (2010) Indole- and indazole-based inhibitors of dipeptidyl peptidase IV for the treatment of type 2 diabetes. 32nd Annual National Medicinal Chemistry Symposium Poster 52
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