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PLpro inhibitor 19

Cat. No. 7505 Submit a Review Datasheet / COA / SDS
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Description: SARS-CoV-2 PLpro and replication inhibitor
Chemical Name: (R)-N-(3-Fluoro-5-((1-(1-(naphthalen-1-yl)ethyl)piperidine-4-carboxamido)methyl)phenyl)-4-methylpiperazine-1-carboxamide
Purity: ≥98% (HPLC)
Datasheet
Citations
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Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for PLpro inhibitor 19

PLpro inhibitor 19 is a SARS-CoV-2 inhibitor that inhibits viral replication and PLpro enzymatic activity in vitro (IC50 values are 0.18 μM and 0.44 μM respectively). PLpro inhibitor 19 is selective for PLpro over human deubiquitinating enzymes (DUBs) and DUB-like proteases and displays no cytotoxicity at up to 10 μM.

Technical Data for PLpro inhibitor 19

M. Wt 531.68
Formula C31H38FN5O2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 2863607-73-0
PubChem ID 155925847
InChI Key ZGUISYSWQQIAHK-JOCHJYFZSA-N
Smiles CN1CCN(CC1)C(NC2=CC(F)=CC(CNC(C3CCN(CC3)[C@@H](C4=C5C=CC=CC5=CC=C4)C)=O)=C2)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for PLpro inhibitor 19

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 53.17 100
ethanol 53.17 100

Preparing Stock Solutions for PLpro inhibitor 19

The following data is based on the product molecular weight 531.68. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.88 mL 9.4 mL 18.81 mL
5 mM 0.38 mL 1.88 mL 3.76 mL
10 mM 0.19 mL 0.94 mL 1.88 mL
50 mM 0.04 mL 0.19 mL 0.38 mL

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Product Datasheets for PLpro inhibitor 19

Certificate of Analysis / Product Datasheet
Safety Datasheet

References for PLpro inhibitor 19

References are publications that support the biological activity of the product.

Shan et al (2021) Development of potent and selective inhibitors targeting the papain-like protease of SARS-CoV-2. Cell Chem.Biol. 28 855 PMID: 33979649

If you know of a relevant reference for PLpro inhibitor 19, please let us know.

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Citations for PLpro inhibitor 19

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