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Description: High affinity FP prostaglandin receptor agonist
Alternative Names: Travoprost acid
Chemical Name: (5Z)-7-[(1R,2R,3R,5S)-3,5-Dihydroxy-2-[(1E,3R)-3-hydroxy-4-[3-(trifluoromethyl)phenoxy]-1-buten-1-yl]cyclopentyl]-5-heptenoic acid
Purity: ≥95% (HPLC)
Biological Activity for (+)-Fluprostenol
(+)-Fluprostenol is a prostaglandin F2α (FP) receptor agonist (Ki = 49.9 nM; EC50 = 2.4 nM). Stimulates intracellular calcium mobilization in cloned human ocular FP receptors, rat A7r5 cells and mouse 3T3 cells (EC50 values are 17.5, 19.1 and 37.3 nM respectively). Analog of prostaglandin F2α. Isopropyl ester travaprost (Cat. No. 4218) also available.
Technical Data for (+)-Fluprostenol
| M. Wt | 458.47 |
| Formula | C23H29F3O6 |
| Storage | Store at -20°C |
| Purity | ≥95% (HPLC) |
| CAS Number | 54276-17-4 |
| PubChem ID | 5311100 |
| InChI Key | WWSWYXNVCBLWNZ-QIZQQNKQSA-N |
| Smiles | O[C@@H]1C[C@H](O)[C@H](C/C=C\CCCC(O)=O)[C@H]1/C=C/[C@@H](O)COC2=CC=CC(C(F)(F)F)=C2 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for (+)-Fluprostenol
References for (+)-Fluprostenol
References are publications that support the biological activity of the product.
Kelly et al (2003) Real-time intracellular Ca2+ mobilization by travo. acid, bimatoprost, unoprostone, and other analogs via endogenous mouse, rat and cloned human FP prostaglandin receptors. J.Pharmacol.Exp.Ther. 304 238 PMID: 12490597
Sharif et al (2003) Human trabecular meshwork cell responses induced by bimatoprost, travoprost, unoprostone, and other EP prostaglandin receptor agonist analogues. Invest.Ophthalmol.Vis.Sci. 44 715 PMID: 12556403
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Keywords: (+)-Fluprostenol, (+)-Fluprostenol supplier, Travoprost, acid, prostaglandin, F2alpha, F2a, F2α, receptors, agonists, Prostanoid, Receptors, 4542, Tocris Bioscience
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