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Submit ReviewPNU 37883 hydrochloride
Description: Vascular Kir6 (KATP) channel blocker
Chemical Name: N-Cyclohexyl-N'-tricyclo[3.3.1.13,7]dec-1-yl-4-morpholinecarboximidamide hydrochloride
Purity: ≥99% (HPLC)
Biological Activity for PNU 37883 hydrochloride
PNU 37883 hydrochloride is a novel antagonist selective for the vascular form of Kir6 (KATP) channel; inhibits Kir6 currents in isolated mesenteric artery smooth muscle cells (Kd = 65 nM) but not in cardiac or skeletal myocytes. Inhibits blood vessel relaxation and hypotension induced by pinacidil in vivo. Displays weak diuretic effects.
Compound Libraries for PNU 37883 hydrochloride
PNU 37883 hydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for PNU 37883 hydrochloride
| M. Wt | 381.98 |
| Formula | C21H35N3O.HCl |
| Storage | Desiccate at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 57568-80-6 |
| PubChem ID | 64392 |
| InChI Key | FZALCKUJYZCDOX-UHFFFAOYSA-N |
| Smiles | C1(CC3C2)CC2(/N=C(N5CCOCC5)/NC4CCCCC4)CC(C3)C1.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for PNU 37883 hydrochloride
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 9.55 | 25 | |
| ethanol | 38.2 | 100 |
Preparing Stock Solutions for PNU 37883 hydrochloride
The following data is based on the product molecular weight 381.98. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.62 mL | 13.09 mL | 26.18 mL |
| 5 mM | 0.52 mL | 2.62 mL | 5.24 mL |
| 10 mM | 0.26 mL | 1.31 mL | 2.62 mL |
| 50 mM | 0.05 mL | 0.26 mL | 0.52 mL |
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Product Datasheets for PNU 37883 hydrochloride
References for PNU 37883 hydrochloride
References are publications that support the biological activity of the product.
Humphrey and Ludens (1998) KATP-blocking diuretic PNU-37883A reduces plasma renin activity in dogs. J.Cardiovasc.Pharmacol. 31 894 PMID: 9641474
Cui et al (2003) Different molecular sites of action for the KATP channel inhibitors, PNU-99963 and PNU-37883A. Br.J.Pharmacol. 139 122 PMID: 12746230
Kovalev et al (2004) Molecular analysis of the subtype-selective inhibition of cloned KATP channels by PNU-37883A. Br.J.Pharmacol. 141 867 PMID: 14757705
If you know of a relevant reference for PNU 37883 hydrochloride, please let us know.
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Keywords: PNU 37883 hydrochloride, PNU 37883 hydrochloride supplier, Vascular, KATP, channels, blockers, Potassium, KIR, Inward, Rectifier, K+, PNU37883, hydrochloride, antagonist, Kir6, rectifier, Channels, 2095, Tocris Bioscience
Citations for PNU 37883 hydrochloride
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Reviews for PNU 37883 hydrochloride
Average Rating: 4 (Based on 1 Review.)
Have you used PNU 37883 hydrochloride?
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PNU 37883 was used to understand whether it shows BK channel blocking effect.
By
Anonymous on 10/31/2018
Assay Type: In Vitro
Species: Human
PNU 37883 was used to understand whether it shows BK channel blocking effect. The product worked ideally although inhibition data obtained from the product shows variation.
I suggest using an alternate channel blocker to measure blocking action to identify the variation with PNU 37883.
