Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewPSB 12379
Description: Ecto-5'-nucleotidase (CD73) inhibitor
Chemical Name: N6-Benzyl-α,β-methyleneadenosine 5'-diphosphate disodium salt
Purity: ≥98% (HPLC)
Biological Activity for PSB 12379
PSB 12379 is a selective high affinity ecto-5'-nucleotidase/CD73 inhibitor (Ki values are 2.21 and 9.03 nM at human and rat CD73, respectively). Blocks ecto-5'-nucleotidase-mediated adenosine production by preventing the conversion of AMP to adenosine. Exhibits selectivity over other ecto-nucleotidases and ADP-activated P2Y receptors tested.
Technical Data for PSB 12379
| M. Wt | 559.31 |
| Formula | C18H21N5Na2O9P2 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| PubChem ID | 131648246 |
| InChI Key | CGXINRNHTNDEBI-BUPZQQHBSA-L |
| Smiles | O[C@H]1[C@@H](O)[C@H](N2C3=NC=NC(NCC4=CC=CC=C4)=C3N=C2)O[C@@H]1COP(CP(O)(O[Na])=O)(O[Na])=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for PSB 12379
| Solubility | Soluble in water (supplied pre-dissolved at a concentration of 10mM) |
Product Datasheets for PSB 12379
References for PSB 12379
References are publications that support the biological activity of the product.
Bhattarai et al (2015) α,β-methylene-ADP (AOPCP) derivatives and analogues: development of potent and selective ecto-5'-nucleotidase (CD73) inhibitors. J.Med.Chem. 58 6248 PMID: 26147331
Weinmann et al (2016) Cancer immunotherapy: selected targets and small-molecule modulators. Chem.Med.Chem. 11 450 PMID: 26836578
If you know of a relevant reference for PSB 12379, please let us know.
View Related Products by Product Action
Keywords: PSB 12379, PSB 12379 supplier, PSB12379, selective, high, affinity, CD73, inhibitors, inhibits, 1802226-78-3, NTPDase, 6083, Tocris Bioscience
2 Citations for PSB 12379
Citations are publications that use Tocris products. Selected citations for PSB 12379 include:
Hyunjung et al (2020) Activation of Astrocytes in the Dorsomedial Striatum Facilitates Transition From Habitual to Goal-Directed Reward-Seeking Behavior. Biol Psychiatry 88 797-808 PMID: 32564901
Istvan et al (2022) Microglial control of neuronal development via somatic purinergic junctions. Cell Rep 40 111369 PMID: 36130488
Do you know of a great paper that uses PSB 12379 from Tocris? Please let us know.
Reviews for PSB 12379
There are currently no reviews for this product. Be the first to review PSB 12379 and earn rewards!
Have you used PSB 12379?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
P2X and P2Y Receptors Scientific Review
Written by Kenneth Jacobson, this review provides an overview of the different subtypes and structures of the P2 receptor families, as well as the pharmacological probes used to study them; compounds available from Tocris are listed.