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Submit ReviewPSB 12379
Description: Ecto-5'-nucleotidase (CD73) inhibitor
Chemical Name: N6-Benzyl-α,β-methyleneadenosine 5'-diphosphate disodium salt
Purity: ≥98% (HPLC)
Biological Activity for PSB 12379
PSB 12379 is a selective high affinity ecto-5'-nucleotidase/CD73 inhibitor (Ki values are 2.21 and 9.03 nM at human and rat CD73, respectively). Blocks ecto-5'-nucleotidase-mediated adenosine production by preventing the conversion of AMP to adenosine. Exhibits selectivity over other ecto-nucleotidases and ADP-activated P2Y receptors tested.
Technical Data for PSB 12379
| M. Wt | 559.31 |
| Formula | C18H21N5Na2O9P2 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| PubChem ID | 131648246 |
| InChI Key | CGXINRNHTNDEBI-BUPZQQHBSA-L |
| Smiles | O[C@H]1[C@@H](O)[C@H](N2C3=NC=NC(NCC4=CC=CC=C4)=C3N=C2)O[C@@H]1COP(CP(O)(O[Na])=O)(O[Na])=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for PSB 12379
| Solubility | Soluble in water (supplied pre-dissolved at a concentration of 10mM) |
Product Datasheets for PSB 12379
References for PSB 12379
References are publications that support the biological activity of the product.
Bhattarai et al (2015) α,β-methylene-ADP (AOPCP) derivatives and analogues: development of potent and selective ecto-5'-nucleotidase (CD73) inhibitors. J.Med.Chem. 58 6248 PMID: 26147331
Weinmann et al (2016) Cancer immunotherapy: selected targets and small-molecule modulators. Chem.Med.Chem. 11 450 PMID: 26836578
If you know of a relevant reference for PSB 12379, please let us know.
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Keywords: PSB 12379, PSB 12379 supplier, PSB12379, selective, high, affinity, CD73, inhibitors, inhibits, 1802226-78-3, NTPDase, 6083, Tocris Bioscience
2 Citations for PSB 12379
Citations are publications that use Tocris products. Selected citations for PSB 12379 include:
Istvan et al (2022) Microglial control of neuronal development via somatic purinergic junctions. Cell Rep 40 111369 PMID: 36130488
Hyunjung et al (2020) Activation of Astrocytes in the Dorsomedial Striatum Facilitates Transition From Habitual to Goal-Directed Reward-Seeking Behavior. Biol Psychiatry 88 797-808 PMID: 32564901
Do you know of a great paper that uses PSB 12379 from Tocris? Please let us know.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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P2X and P2Y Receptors Scientific Review
Written by Kenneth Jacobson, this review provides an overview of the different subtypes and structures of the P2 receptor families, as well as the pharmacological probes used to study them; compounds available from Tocris are listed.