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Submit ReviewPyrrolidinedithiocarbamate ammonium
Description: Inhibits NF-κB, prevents increase in NOS mRNA
Alternative Names: PDTC
Biological Activity for Pyrrolidinedithiocarbamate ammonium
This inhibitor of nuclear factor κB (NF-κB) prevents the increase in NO-synthase mRNA by interleukin-1, without affecting the formation of NO-synthase mRNA produced by cAMP.
Technical Data for Pyrrolidinedithiocarbamate ammonium
| M. Wt | 164.28 |
| Formula | C5H12N2S2 |
| Storage | Store at RT |
| CAS Number | 5108-96-3 |
| PubChem ID | 73343 |
| InChI Key | MDDIUTVUBYEEEM-UHFFFAOYSA-N |
| Smiles | [NH4+].[S-]C(N1CCCC1)=S |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Pyrrolidinedithiocarbamate ammonium
References for Pyrrolidinedithiocarbamate ammonium
References are publications that support the biological activity of the product.
Bessho et al (1994) Pyrrolidine dithiocarbamate, a potent inhibitor of nuclear factor κB (NF-κB) activation, prevents apoptosis in human promyelocytic leukemia HL-60 cells and thymocytes. Biochem.Pharmacol. 48 1883 PMID: 7986199
Eberhardt et al (1994) Pyrrolidine dithiocarbamate differentially affects 1β- and cAMP-induced NO-synthase expression in rat renal mesangial cells. Biochem.Biophys.Res.Commun. 200 163 PMID: 7513157
Schini-Kerth (1994) Pyrrolidine dithiocarbamate selectively prevents the expression of the inducible nitric oxide synthase in the rat aorta. Eur.J.Pharmacol. 265 83 PMID: 7533726
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Keywords: Pyrrolidinedithiocarbamate ammonium, Pyrrolidinedithiocarbamate ammonium supplier, inhibitors, inhibits, NF-κB, NF-kappaB, NF-kB, NOS, mRNA, NFκB, NFkappaB, Nitric, Oxide, Signaling, Signalling, IκB, IkappaB, Nuclear, Factor, Kappa, B, Transcription, Factors, PDTC, Other, NF-kB/IkB, 0727, Tocris Bioscience
8 Citations for Pyrrolidinedithiocarbamate ammonium
Citations are publications that use Tocris products. Selected citations for Pyrrolidinedithiocarbamate ammonium include:
Ishizuka et al (2016) PAFR activation of NF-& #954;B p65 or p105 precursor dictates pro-and anti-inflammatory responses during TLR activation in murine macrophages Scientific Reports 6 32092 PMID: 27554194
Muxel et al (2013) NF-κB drives the synthesis of melatonin in RAW 264.7 macrophages by inducing the transcription of the arylalkylamine-N-acetyltransferase (AA-NAT) gene. BMC Cancer 7 e52010 PMID: 23284853
Birmingham et al (2009) Novel mechanism for obesity-induced colon cancer progression. Carcinogenesis 30 690 PMID: 19221001
Nadeem (2017) IL-17A causes depression-like symptoms via NFκB and p38MAPK signaling pathways in mice: Implications for psoriasis associated depression. Cytokine 97 14 PMID: 28570931
Li et al (2017) Follicular Stimulating Hormone Accelerates Atherogenesis by Increasing Endothelial VCAM-1 Expression. Theranostics 7 4671 PMID: 29187895
Clement et al (2014) CD31 is a key coinhibitory receptor in the development of immunogenic dendritic cells. Proc Natl Acad Sci U S A 111 E1101 PMID: 24616502
Wang et al (2015) Downregulation of toll-like receptor 4 induces suppressive effects on hepatitis B virus-related hepatocellular carcinoma via ERK1/2 signaling. Sci Rep 15 821 PMID: 26514586
Lin et al (2015) Kallistatin protects against sepsis-related acute lung injury via inhibiting inflammation and apoptosis. J Neurosci 5 12463 PMID: 26198099
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PDTC inhibits HOCl-LDL-induced CaMKII oxidation.
By
Chintan Koyani on 10/22/2018
Assay Type: In Vitro
Species: Mouse
Cell Line/Tissue: Cardiomyocytes
HL-1 cardiomyocytes were pre-treated with Pyrrolidinedithiocarbamate (PDTC, 1 mM), Tempol (1 mM) or N-Acetylcysteine (NAC, 1 mM) for 30 min and stimulated with HOCl-LDL (200 µg/ml) for 2 h to follow CaMKII oxidation using Western blot.
Pathways for Pyrrolidinedithiocarbamate ammonium
