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Submit ReviewQAQ dichloride
Description: Photoswitchable Nav, Kv and Cav channel blocker
Chemical Name: 2,2'-[1,2-Diazenediylbis(4,1-phenyleneimino)bis[N,N,N-triethyl-2-oxo-ethanaminium] dichloride
Purity: ≥98% (HPLC)
Biological Activity for QAQ dichloride
QAQ dichloride is a photoswitchable Nav, Cav and Kv channel blocker. Blocks channels in the trans conformation. Switches conformation from cis to trans at 500 nm and trans to cis at 380 nm. Normally membrane impermeant, but enters nociceptive neurons via ion channels activated by noxious stimuli, particularly TRPV1. Exhibits optically reversible local anesthesia in rats.
Technical Data for QAQ dichloride
| M. Wt | 567.59 |
| Formula | C28H44Cl2N6O2 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| PubChem ID | 91826091 |
| InChI Key | VHURBRSYOFCHNY-UHFFFAOYSA-N |
| Smiles | O=C(C[N+](CC)(CC)CC)NC(C=C2)=CC=C2/N=N/C1=CC=C(NC(C[N+](CC)(CC)CC)=O)C=C1.[Cl-].[Cl-] |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for QAQ dichloride
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 28.38 | 50 |
Preparing Stock Solutions for QAQ dichloride
The following data is based on the product molecular weight 567.59. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 3.52 mL | 17.62 mL | 35.24 mL |
| 2.5 mM | 0.7 mL | 3.52 mL | 7.05 mL |
| 5 mM | 0.35 mL | 1.76 mL | 3.52 mL |
| 25 mM | 0.07 mL | 0.35 mL | 0.7 mL |
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Product Datasheets for QAQ dichloride
References for QAQ dichloride
References are publications that support the biological activity of the product.
Mourot et al (2012) Rapid optical control of nociception with an ion-channel photoswitch. Nat.Methods 9 396 PMID: 22343342
Banghart MR et al (2009) Photochromic blockers of voltage-gated potassium channels. Angew.Chem.Int.Ed. 48 9097 PMID: 19882609
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Keywords: QAQ dichloride, QAQ dichloride supplier, photoswitchable, Kv, potassium, channels, K+, blockers, Ca2+, Cav, calcium, Na+, Nav, sodium, local, anesthesia, anesthetic, ligands, Photoswitchable, Ligands, Non-selective, Channels, Voltage-Gated, Potassium, Voltage-gated, Sodium, 5470, Tocris Bioscience
1 Citation for QAQ dichloride
Citations are publications that use Tocris products. Selected citations for QAQ dichloride include:
Nikolaev et al (2022) Development of a quaternary ammonium photoswitchable antagonist of NMDA receptors. Eur.J.Pharmacol. 938 175448 PMID: 36470444
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