Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewQM-FN-SO3
Description: Blood-brain barrier penetrant, NIR aggregation-induced emission active probe of amyloid β plaques. Used for: in vitro, in situ and in vivo imaging of amyloid β plaques. Application: confocal microscopy and in vivo imaging
Chemical Name: Sodium 3-(4-(Dicyanomethylene)-2-(2-(5-(4-(dimethylamino)phenyl)thiophen-2-yl)vinyl)quinolin-1(4H)-yl)propane-1-sulfonate
Purity: ≥95% (HPLC)
Biological Activity for QM-FN-SO3
Key information: QM-FN-SO3 is a near-infrared (NIR) aggregation-induced emission active probe for in vivo imaging of amyloid β (Aβ) plaques. Blood brain barrier penetrant.
Used for: detection of Aβ plaques in vitro, in situ and in vivo.
Application: confocal microscopy and in vivo imaging.
Properties and Photophysical Data: QM-FN-SO3 shows high binding affinity, ultra-high sensitivity, low signal-to-noise ratio, and large stokes shift (170 nm) reducing excitation light-induced self-quenching. Excitation and emission maxima (λ) are 488 nm and 680 nm, respectively.
Optical Data for QM-FN-SO3
| λabs | 488 nm |
|---|---|
| λem | 680 nm |
| Cell Permeable | Yes |
| Application | Confocal imaging of amyloid-beta plaques, in vitro and in vivo |
Plan Your Experiments
Use our spectra viewer to interactively plan your experiments, assessing multiplexing options. View the excitation and emission spectra for our fluorescent dye range and other commonly used dyes.
Spectral Viewer
Technical Data for QM-FN-SO3
| M. Wt | 564.65 |
| Formula | C29H25N4O3S2.Na |
| Storage | Store at -20°C |
| Purity | ≥95% (HPLC) |
| CAS Number | 2316820-94-5 |
| PubChem ID | 154727758 |
| InChI Key | WYMGXQAGHDNQOV-UEIGIMKUSA-M |
| Smiles | CN(C)C1=CC=C(C=C1)C2=CC=C(S2)/C=C/C(N(CCCS(=O)([O-])=O)C3=C/4C=CC=C3)=CC4=C(C#N)/C#N.[Na+] |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for QM-FN-SO3
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 28.23 | 50 | |
| water | 11.29 | 20 |
Preparing Stock Solutions for QM-FN-SO3
The following data is based on the product molecular weight 564.65. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 3.54 mL | 17.71 mL | 35.42 mL |
| 2.5 mM | 0.71 mL | 3.54 mL | 7.08 mL |
| 5 mM | 0.35 mL | 1.77 mL | 3.54 mL |
| 25 mM | 0.07 mL | 0.35 mL | 0.71 mL |
Molarity Calculator
Molarity Calculator
Calculate the mass, volume, or concentration required for a solution.
Reconstitution Calculator
Reconstitution Calculator
Dilution Calculator
Dilution Calculator
Calculate the dilution required to prepare a stock solution.
Product Datasheets for QM-FN-SO3
References for QM-FN-SO3
References are publications that support the biological activity of the product.
Yan et al (2023) Preparation of near-infrared AIEgen-active fluorescent probes for mapping amyloid-β plaques in brain tissues and living mice. Nat.Protoc. 18 1316 PMID: 36697872
Fu et al (2019) Rational design of near-infrared aggregation-induced-emission-active probes: in situ mapping of amyloid-β plaques with ultrasensitivity and high-fidelity. J.Am.Chem.Soc. 141 3171 PMID: 30632737
Su et al (2022) Strategic design of amyloid-β species fluorescent probes for Alzheimer's disease. ACS Chem.Neurosci. 13 540 PMID: 35132849
If you know of a relevant reference for QM-FN-SO3, please let us know.
View Related Products by Target
Keywords: QM-FN-SO3, QM-FN-SO3 supplier, Alzheimer's, disease, alzheimers, amyloid-β, species, near-infrared, NIR, fluorescent, probes, diagnosis, AB, amyloid-beta, beta-amyloid, aggregates, plaques, amyloidβ, amyloid, beta, brain, penetrant, peptides, Fluorescent, Amyloid, B, Probes, Beta, Peptides, 7958, Tocris Bioscience
Citations for QM-FN-SO3
Citations are publications that use Tocris products.
Currently there are no citations for QM-FN-SO3. Do you know of a great paper that uses QM-FN-SO3 from Tocris? Please let us know.
Reviews for QM-FN-SO3
There are currently no reviews for this product. Be the first to review QM-FN-SO3 and earn rewards!
Have you used QM-FN-SO3?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Fluorescent Dyes and Probes Research Product Guide
This product guide provides a background to the use of Fluorescent Dyes and Probes, as well as a comprehensive list of our:
- Fluorescent Dyes, including dyes for flow cytometry
- Fluorescent Probes and Stains, including our new MitoBrilliantTM mitochondria stains
- Tissue Clearing Kits and Reagents
- Aptamer-based RNA Imaging Reagents
- Fluorescent Probes for Imaging Bacteria
- TSA VividTM Fluorophore Kits
- TSA Reagents for Enhancing IHC, ICC & FISH Signals