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Submit ReviewRCM 1
Description: FOXM1 inhibitor
Chemical Name: 2-[[2-Oxo-2-(2-thienyl)ethyl]thio]-4,6-di-2-thienyl-3-pyridinecarbonitrile
Purity: ≥98% (HPLC)
Biological Activity for RCM 1
RCM 1 is a forkhead box M1 (FOXM1) transcription factor inhibitor (IC50 = 0.72 μM). Inhibits expression of FOXM1 target genes. Induces FOXM1 protein degradation in vitro. Reduces airway resistance, increases lung compliance and decreases proinflammatory cytokine production in allergen-exposed mice.
Technical Data for RCM 1
| M. Wt | 424.58 |
| Formula | C20H12N2OS4 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 339163-65-4 |
| PubChem ID | 4273985 |
| InChI Key | DCCYTKKDAZEVLY-UHFFFAOYSA-N |
| Smiles | O=C(C1=CC=CS1)CSC2=C(C(C3=CC=CS3)=CC(C4=CC=CS4)=N2)C#N |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for RCM 1
References for RCM 1
References are publications that support the biological activity of the product.
Sun et al (2017) The FOXM1 inhibitor RCM-1 suppresses goblet cell metaplasia and prevents IL-13 and STAT6 signaling in allergen-exposed mice. Sci.Signal. 10 eaai8583 PMID: 28420758
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Keywords: RCM 1, RCM 1 supplier, RCM1, forkhead, box, m1, FOXM1, transcription, factor, inhibitors, inhibits, allergy, cytokine, production, goblet, cells, anti-inflammatory, anti-asthma, Other, Transcription, Factors, 6845, Tocris Bioscience
Citations for RCM 1
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