RG 108

Pricing Availability   Qty
Description: Non-nucleoside DNA methyltransferase inhibitor
Chemical Name: N-Phthalyl-L-tryptophan
Purity: ≥99% (HPLC)
Datasheet
Citations (3)
Reviews (2)
Literature (3)

Biological Activity for RG 108

RG 108 is a non-nucleoside DNA methyltransferase inhibitor that blocks the enzyme active site. Inhibits DNA methylation in human cancer cell lines in vitro without detectable toxicity. Demethylates and reactivates epigenetically silenced tumor suppressor genes. Enhances the efficiency of induced pluripotent stem cell (iPS) generation.

Compound Libraries for RG 108

RG 108 is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Epigenetics Library and Tocriscreen Stem Cell Library. Find out more about compound libraries available from Tocris.

Technical Data for RG 108

M. Wt 334.33
Formula C19H14N2O4
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 48208-26-0
PubChem ID 702558
InChI Key HPTXLHAHLXOAKV-INIZCTEOSA-N
Smiles O=C(C(C=CC=C4)=C4C3=O)N3[C@H](C(O)=O)CC2=CNC1=CC=CC=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for RG 108

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 33.43 100
ethanol 33.43 100

Preparing Stock Solutions for RG 108

The following data is based on the product molecular weight 334.33. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.99 mL 14.96 mL 29.91 mL
5 mM 0.6 mL 2.99 mL 5.98 mL
10 mM 0.3 mL 1.5 mL 2.99 mL
50 mM 0.06 mL 0.3 mL 0.6 mL

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Product Datasheets for RG 108

Certificate of Analysis / Product Datasheet
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References for RG 108

References are publications that support the biological activity of the product.

Brueckner et al (2005) Epigenetic reactivation of tumor suppressor genes by a novel small-molecule inhibitor of DNA methyltransferase. Cancer Res. 65 6305 PMID: 16024632

Stresemann et al (2006) Functional diversity of DNA methyltransferase inhibitors in human cancer cell lines. Cancer Res. 66 2794 PMID: 16510601

Schirrmacher et al (2006) Synthesis and in vitro evaluation of biotinylated RG108: a high affinity compound for studying binding interactions with human DNA methyltransferases. Bioconjug.Chem. 17 261 PMID: 16536454


If you know of a relevant reference for RG 108, please let us know.

View Related Products by Product Action

View all DNA Methyltransferase Inhibitors

Keywords: RG 108, RG 108 supplier, Non-nucleoside, DNA, methyltransferase, inhibitor, inhibitors, transferases, RG108, inhibits, methylation, dnmt, epigenetics, Methyltransferases, Stem, Cell, Reprogramming, 3295, Tocris Bioscience

3 Citations for RG 108

Citations are publications that use Tocris products. Selected citations for RG 108 include:

Zhang et al (2016) Pharmacological reprogramming of fibroblasts into neural stem cells by signaling-directed transcriptional activation. Cell Stem Cell 18 653 PMID: 27133794

Kottakis et al (2016) LKB1 loss links serine metabolism to DNA methylation and tumorigenesis. Nature 539 390 PMID: 27799657

Nugent et al (2015) Brain feminization requires active repression of masculinization via DNA methylation. PLoS One 18 690 PMID: 25821913


Do you know of a great paper that uses RG 108 from Tocris? Please let us know.

Reviews for RG 108

Average Rating: 5 (Based on 2 Reviews.)

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Highly stable.
By Anonymous on 06/25/2020
Assay Type: In Vitro
Species: Mouse
Cell Line/Tissue: Neural Stem Cells

Cells are treated with 10 µM RG 108

PMID: 27133794
review image

We got expected effect on cells.
By Anonymous on 04/03/2020
Assay Type: In Vitro
Species: Mouse
Cell Line/Tissue: Primary pancreatic ductal epithelial cells

100 μM RG108

review image

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


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