Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewRN 1 dihydrochloride
Description: LSD1 inhibitor
Chemical Name: 1-(4-methyl-1-piperazinyl)-2-[[(1R*,2S*)-2-[4-phenylmethoxy)phenyl]cyclopropyl]amino]ethanone dihydrochloride
Purity: ≥97% (HPLC)
Biological Activity for RN 1 dihydrochloride
RN 1 dihydrochloride is a potent lysine specific demethylase 1 (LSD1) inhibitor (IC50 = 70 nM). Exhibits selectivity for LSD1 over MAO-A and MAO-B (IC50 values are 0.51 and 2.79 μM for MAO-A and MAO-B, respectively). Impairs long-term, but not short-term memory in mice. Brain penetrant following systemic administration.
Compound Libraries for RN 1 dihydrochloride
RN 1 dihydrochloride is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Epigenetics Library. Find out more about compound libraries available from Tocris.
Technical Data for RN 1 dihydrochloride
| M. Wt | 452.42 |
| Formula | C23H29N3O2.2HCl |
| Storage | Store at -20°C |
| Purity | ≥97% (HPLC) |
| CAS Number | 1781835-13-9 |
| PubChem ID | 90488995 |
| InChI Key | WMHAFZOOUBPQRX-VSIGASKDSA-N |
| Smiles | O=C(N4CCN(C)CC4)CN[C@@H]1C[C@H]1[C@]2=CC=C(OCC3=CC=CC=C3)C=C2.Cl.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for RN 1 dihydrochloride
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 9.05 | 20 | |
| DMSO | 9.05 | 20 with gentle warming |
Preparing Stock Solutions for RN 1 dihydrochloride
The following data is based on the product molecular weight 452.42. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.2 mM | 11.05 mL | 55.26 mL | 110.52 mL |
| 1 mM | 2.21 mL | 11.05 mL | 22.1 mL |
| 2 mM | 1.11 mL | 5.53 mL | 11.05 mL |
| 10 mM | 0.22 mL | 1.11 mL | 2.21 mL |
Molarity Calculator
Molarity Calculator
Calculate the mass, volume, or concentration required for a solution.
Reconstitution Calculator
Reconstitution Calculator
Dilution Calculator
Dilution Calculator
Calculate the dilution required to prepare a stock solution.
Product Datasheets for RN 1 dihydrochloride
References for RN 1 dihydrochloride
References are publications that support the biological activity of the product.
Neelamegam et al (2012) Brain-penetrant LSD1 inhibitors can block memory consolidation. ACS Chem.Neurosci. 3 120 PMID: 22754608
If you know of a relevant reference for RN 1 dihydrochloride, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: RN 1 dihydrochloride, RN 1 dihydrochloride supplier, RN1, dihydrochloride, LSD1, lysine-specific, demethylase, 1, histone, demethylases, monoamine, oxidases, MAOs, inhibitors, inhibits, selective, Histone, Demethylases, 4977, Tocris Bioscience
1 Citation for RN 1 dihydrochloride
Citations are publications that use Tocris products. Selected citations for RN 1 dihydrochloride include:
Llewellyn et al (2018) HIV-1 infection of microglial cells in a reconstituted humanized mouse model and identification of compounds that selectively reverse HIV latency. J Neurovirol 24 192 PMID: 29256041
Do you know of a great paper that uses RN 1 dihydrochloride from Tocris? Please let us know.
Reviews for RN 1 dihydrochloride
There are currently no reviews for this product. Be the first to review RN 1 dihydrochloride and earn rewards!
Have you used RN 1 dihydrochloride?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Epigenetics Scientific Review
Written by Susanne Müller-Knapp and Peter J. Brown, this review gives an overview of the development of chemical probes for epigenetic targets, as well as the impact of these tool compounds being made available to the scientific community. In addition, their biological effects are also discussed. Epigenetic compounds available from Tocris are listed.