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Submit ReviewRP 001 hydrochloride
Description: Potent S1P1 agonist
Chemical Name: N-[4-[5-[3-Cyano-4-(1-methylethoxy)phenyl]-1,2,4-oxadiazol-3-yl]-2,3-dihydro-1H-inden-1-yl]-β-alanine hydrochloride
Purity: ≥98% (HPLC)
Biological Activity for RP 001 hydrochloride
RP 001 hydrochloride is a potent agonist of S1P1 receptors (EC50 = 9 pM). Induces internalization and polyubiquitination of S1P1 in vitro. Selective for S1P1 over S1P2 - S1P4.
Compound Libraries for RP 001 hydrochloride
RP 001 hydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for RP 001 hydrochloride
| M. Wt | 468.93 |
| Formula | C24H24N4O4.HCl |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1781880-34-9 |
| PubChem ID | 90488927 |
| InChI Key | ZHPGSGYEFGEZAL-UHFFFAOYSA-N |
| Smiles | CC(C)OC1=C(C#N)C=C(C2=NC(C3=C(CCC4NCCC(O)=O)C4=CC=C3)=NO2)C=C1.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for RP 001 hydrochloride
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 43.25 | 100 |
Preparing Stock Solutions for RP 001 hydrochloride
The following data is based on the product molecular weight 468.93. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.13 mL | 10.66 mL | 21.33 mL |
| 5 mM | 0.43 mL | 2.13 mL | 4.27 mL |
| 10 mM | 0.21 mL | 1.07 mL | 2.13 mL |
| 50 mM | 0.04 mL | 0.21 mL | 0.43 mL |
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Product Datasheets for RP 001 hydrochloride
References for RP 001 hydrochloride
References are publications that support the biological activity of the product.
Cahalan et al (2011) Actions of a picomolar short-acting S1P1 agonist in S1P1-eGFP knock-in mice. Nat.Chem.Biol. 7 254 PMID: 21445057
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Keywords: RP 001 hydrochloride, RP 001 hydrochloride supplier, RP001, sphingosine, 1, phosphate, s1p1, receptors, agonists, selective, Sphingosine-1-phosphate, Receptors, 4289, Tocris Bioscience
2 Citations for RP 001 hydrochloride
Citations are publications that use Tocris products. Selected citations for RP 001 hydrochloride include:
Masato et al (2018) Turbulence Activates Platelet Biogenesis to Enable Clinical Scale Ex Vivo Production. Cell 174 636-648.e18 PMID: 30017246
Li et al (2019) RP001 hydrochloride improves neurological outcome after subarachnoid hemorrhage. J.Neurol.Sci. 399 6 PMID: 30738334
Do you know of a great paper that uses RP 001 hydrochloride from Tocris? Please let us know.
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