Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewRucaparib camsylate
Description: PARP inhibitor
Alternative Names: CO-338
Chemical Name: 8-Fluoro-1,3,4,5-tetrahydro-2-[4-[(methylamino)methyl]phenyl]-6H-pyrrolo[4,3,2,ef][2]benzazepin-6-one (1S,4R)-7,7-dimethyl-2-oxobicyclo[2.2.1]heptane-1-methanesulfonic acid
Purity: ≥98% (HPLC)
Biological Activity for Rucaparib camsylate
Rucaparib camsylate is a PARP inhibitor. Chemosensitizes colorectal cancer cells to Temozolomide (Cat. No. 2706) and Topotecan (Cat. No. 4562) in vitro and in vivo.
Licensing Information
Sold for research purposes under agreement from Pfizer Inc.
Compound Libraries for Rucaparib camsylate
Rucaparib camsylate is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Epigenetics Library and Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.
Technical Data for Rucaparib camsylate
| M. Wt | 555.66 |
| Formula | C19H18FN3O.C10H16O4S |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1859053-21-6 |
| PubChem ID | 53356947 |
| InChI Key | INBJJAFXHQQSRW-FHIDHQGESA-N |
| Smiles | CNCC1=CC=C(C2=C3CCNC(C4=C3C(N2)=CC(F)=C4)=O)C=C1.O=S(C[C@@]5(C6(C)C)CC[C@@H]6CC5=O)(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Rucaparib camsylate
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 55.57 | 100 |
Preparing Stock Solutions for Rucaparib camsylate
The following data is based on the product molecular weight 555.66. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.8 mL | 9 mL | 18 mL |
| 5 mM | 0.36 mL | 1.8 mL | 3.6 mL |
| 10 mM | 0.18 mL | 0.9 mL | 1.8 mL |
| 50 mM | 0.04 mL | 0.18 mL | 0.36 mL |
Molarity Calculator
Molarity Calculator
Calculate the mass, volume, or concentration required for a solution.
Reconstitution Calculator
Reconstitution Calculator
Dilution Calculator
Dilution Calculator
Calculate the dilution required to prepare a stock solution.
Product Datasheets for Rucaparib camsylate
References for Rucaparib camsylate
References are publications that support the biological activity of the product.
Thomas et al (2007) Preclinical selection of a novel poly(ADP-ribose) polymerase inhibitor for clinical trial. Mol.Cancer Ther. 6 945 PMID: 17363489
If you know of a relevant reference for Rucaparib camsylate, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: Rucaparib camsylate, Rucaparib camsylate supplier, PARP, inhibitors, inhibits, Poly(ADP-ribose), Polymerase, chemosentizers, chemosensitizes, CO-338, 6230, Tocris Bioscience
Citations for Rucaparib camsylate
Citations are publications that use Tocris products.
Currently there are no citations for Rucaparib camsylate. Do you know of a great paper that uses Rucaparib camsylate from Tocris? Please let us know.
Reviews for Rucaparib camsylate
There are currently no reviews for this product. Be the first to review Rucaparib camsylate and earn rewards!
Have you used Rucaparib camsylate?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Cell Cycle and DNA Damage Research Product Guide
This product guide provides a review of the cell cycle and DNA damage research area and lists over 150 products, including research tools for:
- Cell Cycle and Mitosis
- DNA Damage Repair
- Targeted Protein Degradation
- Ubiquitin Proteasome Pathway
- Chemotherapy Targets
Cell Cycle & DNA Damage Repair Poster
In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. This poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.