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Submit Review(S)-(+)-Dimethindene maleate
Description: Selective M2 antagonist
Chemical Name: N,N-Dimethyl-3-[(1S)-1-(2-pyridinyl)ethyl]-1H-indene-2-ethanamine maleate
Purity: ≥99% (HPLC)
Biological Activity for (S)-(+)-Dimethindene maleate
(S)-(+)-Dimethindene maleate is an enantiomer that is a subtype-selective M2 muscarinic receptor antagonist (pKi values are 7.08, 7.78, 6.70 and 7.00 for M1, M2, M3 and M4 receptors respectively). Also H1 histamine receptor antagonist (pKi = 7.48). Allows formation of extended pluripotent stem (EPS) cells in combination with CHIR 99021 (Cat.No. 4423), minocycline hydrochloride (Cat.No. 3268) and human leukemia inhibitory factor.
For more information about how Dimethindene maleate may be used, see our protocol: Generation and Propagation of EPS cells (LCDM Cocktail).
Technical Data for (S)-(+)-Dimethindene maleate
| M. Wt | 408.5 |
| Formula | C20H24N2.C4H4O4 |
| Storage | Desiccate at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 136152-65-3 |
| PubChem ID | 56972160 |
| InChI Key | SWECWXGUJQLXJF-HFNHQGOYSA-N |
| Smiles | C[C@H](C3=NC=CC=C3)C2=C(CCN(C)C)CC1=CC=CC=C12.OC(=O)\C=C/C(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for (S)-(+)-Dimethindene maleate
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 29.24 | 100 with gentle warming |
Preparing Stock Solutions for (S)-(+)-Dimethindene maleate
The following data is based on the product molecular weight 408.5. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.45 mL | 12.24 mL | 24.48 mL |
| 5 mM | 0.49 mL | 2.45 mL | 4.9 mL |
| 10 mM | 0.24 mL | 1.22 mL | 2.45 mL |
| 50 mM | 0.05 mL | 0.24 mL | 0.49 mL |
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Product Datasheets for (S)-(+)-Dimethindene maleate
References for (S)-(+)-Dimethindene maleate
References are publications that support the biological activity of the product.
Lambrecht et al (1999) Neuronal soma-dendritic and prejunctional M1-M4 receptors in gastrointestinal and genitourinary smooth muscle. Life Sci. 64 403 PMID: 10069503
Pfaff et al (1995) The (S)-(+)-enantiomer of dimethindene: a novel M2-selective muscarinic receptor antagonist. Eur.J.Pharmacol. 286 229 PMID: 8608784
Yang et al (2017) Derivation of pluripotent stem cells with in vivo embryonic and extraembryonic potency. Cell. 169 243 PMID: 28388409
If you know of a relevant reference for (S)-(+)-Dimethindene maleate, please let us know.
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Keywords: (S)-(+)-Dimethindene maleate, (S)-(+)-Dimethindene maleate supplier, H1, antagonists, M2, muscarinic, Receptors, Histamine, Acetylcholine, ACh, histaminergic, Stem, Cell, Reprogramming, 1425, Tocris Bioscience
6 Citations for (S)-(+)-Dimethindene maleate
Citations are publications that use Tocris products. Selected citations for (S)-(+)-Dimethindene maleate include:
Li et al (2018) Rapid generation of gene-targeted EPS-derived mouse models through tetraploid complementation. Protein Cell PMID: 29948855
Du et al (2019) Efficient derivation of extended pluripotent stem cells from NOD-scid Il2rg-/- mice. Protein Cell 10 31 PMID: 29948854
Xu et al (2019) Generation of pig induced pluripotent stem cells using an extended pluripotent stem cell culture system. Stem Cell Res Ther 10 193 PMID: 31248457
Yang et al (2017) Derivation of pluripotent stem cells with in vivo embryonic and extraembryonic potency. Cell 169 243 PMID: 28388409
Matsumoto et al (2010) Differential roles of M2 and M3 muscarinic receptor subtypes in modulation of bladder afferent activity in rats. Urology 75 862 PMID: 20156651
Li et al (2019) Generation of blastocyst-like structures from mouse embryonic and adult cell cultures. Cell 179 687 PMID: 31626770
Do you know of a great paper that uses (S)-(+)-Dimethindene maleate from Tocris? Please let us know.
Reviews for (S)-(+)-Dimethindene maleate
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ESC culture.
By
Anonymous on 11/23/2021
Assay Type: In Vitro
Species: Mouse
Cell Line/Tissue: ESC
In vitro cell culture addition. The image shows the morphology of ESC colonies after conversion by using the treatment condition. This condition supported the conversion and long-term maintenance of dome-shaped ESCs from primed ESCs.
Generation of EPS-blastoids.
By
Anonymous on 02/27/2020
Assay Type: In Vitro
Species: Mouse
Cell Line/Tissue: EPS
2uM
Protocols for (S)-(+)-Dimethindene maleate
The following protocol features additional information for the use of (S)-(+)-Dimethindene maleate (Cat. No. 1425).
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