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Submit ReviewSCH 28080
Discontinued Product
1690 has been discontinued.
View all H<sup>+</sup>,K<sup>+</sup>-ATPase products.
Description: H+,K+-ATPase inhibitor
Chemical Name: 2-Methyl-8-(phenylmethoxy)imidazo[1,2-a]pyridine-3-acetonitrile
Purity: ≥99% (HPLC)
Biological Activity for SCH 28080
SCH 28080 is a potent inhibitor of H+,K+-ATPase (IC50 = 20 nM); binds to the K+ recognition site and is competitive with respect to K+. Inhibits gastric acid secretion in vitro and in vivo.
Technical Data for SCH 28080
| M. Wt | 277.33 |
| Formula | C17H15N3O |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 76081-98-6 |
| PubChem ID | 108137 |
| InChI Key | PYKJFEPAUKAXNN-UHFFFAOYSA-N |
| Smiles | CC1=C(CC#N)N2C=CC=C(OCC3=CC=CC=C3)C2=N1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for SCH 28080
References for SCH 28080
References are publications that support the biological activity of the product.
Long et al (1983) Gastric antisecretory and cytoprotective activities of SCH 28080. J.Pharmacol.Exp.Ther. 226 114 PMID: 6864535
Scott et al (1987) Studies on the mechanism of action of the gastric microsomal (H+K+)-ATPase inhibitors SCH 32651 and SCH 28080. Biochem.Pharmacol. 36 97 PMID: 3026407
Vagin et al (2002) SCH 28080, a K+-competitive inhibitor of the gastric H,K-ATPase, binds near the M5-6 luminal loop, preventing K+ access to the ion binding domain. Biochemistry 41 12755 PMID: 12379118
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Keywords: SCH 28080, SCH 28080 supplier, H+K+-ATPase, inhibitors, inhibits, P-Type, ATPase, Ion, Transporters, Pumps, hydrogen, potassium-ATPase, SCH28080, H+,K+-ATPase, 1690, Tocris Bioscience
1 Citation for SCH 28080
Citations are publications that use Tocris products. Selected citations for SCH 28080 include:
Lynch et al (2010) Heterogeneity of H-K-ATPase-mediated acid secretion along the mouse collecting duct. Am J Physiol Renal Physiol 298 F408 PMID: 19923411
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