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View all H<sup>+</sup>,K<sup>+</sup>-ATPase products.SCH 28080 is a potent inhibitor of H+,K+-ATPase (IC50 = 20 nM); binds to the K+ recognition site and is competitive with respect to K+. Inhibits gastric acid secretion in vitro and in vivo.
M. Wt | 277.33 |
Formula | C17H15N3O |
Storage | Store at RT |
Purity | ≥99% (HPLC) |
CAS Number | 76081-98-6 |
PubChem ID | 108137 |
InChI Key | PYKJFEPAUKAXNN-UHFFFAOYSA-N |
Smiles | CC1=C(CC#N)N2C=CC=C(OCC3=CC=CC=C3)C2=N1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
References are publications that support the biological activity of the product.
Long et al (1983) Gastric antisecretory and cytoprotective activities of SCH 28080. J.Pharmacol.Exp.Ther. 226 114 PMID: 6864535
Scott et al (1987) Studies on the mechanism of action of the gastric microsomal (H+K+)-ATPase inhibitors SCH 32651 and SCH 28080. Biochem.Pharmacol. 36 97 PMID: 3026407
Vagin et al (2002) SCH 28080, a K+-competitive inhibitor of the gastric H,K-ATPase, binds near the M5-6 luminal loop, preventing K+ access to the ion binding domain. Biochemistry 41 12755 PMID: 12379118
Keywords: SCH 28080, SCH 28080 supplier, H+K+-ATPase, inhibitors, inhibits, P-Type, ATPase, Ion, Transporters, Pumps, hydrogen, potassium-ATPase, SCH28080, H+,K+-ATPase, 1690, Tocris Bioscience
Citations are publications that use Tocris products. Selected citations for SCH 28080 include:
Lynch et al (2010) Heterogeneity of H-K-ATPase-mediated acid secretion along the mouse collecting duct. Am J Physiol Renal Physiol 298 F408 PMID: 19923411
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