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Submit ReviewSD 2590 hydrochloride
Description: Potent MMP inhibitor
Alternative Names: SC 78080
Chemical Name: N-Hydroxy-1-(2-methoxyethyl)-4-[4-[4-(trifluoromethoxy)phenoxy]phenyl]sulfonyl]-4-piperidinecarboxamide hydrochloride
Purity: ≥98% (HPLC)
Biological Activity for SD 2590 hydrochloride
SD 2590 hydrochloride is a potent MMP inhibitor (IC50 values are <0.1, <0.1, 0.18, 1.7, 13 and 28.7 nM for MMP-2, -13, -9, -8, -14 and -3 respectively). Exhibits 100,000-fold selectivity for MMP-2 and -13 over MMP-1. Reduces left ventricular dilation in a myocardial infarction rat model. Orally bioavailable.
Licensing Information
Sold for research purposes under agreement from Pfizer Inc
Compound Libraries for SD 2590 hydrochloride
SD 2590 hydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for SD 2590 hydrochloride
| M. Wt | 554.96 |
| Formula | C22H25F3N2O7S.HCl |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 226395-93-3 |
| PubChem ID | 9893894 |
| InChI Key | HJJOIVGDTLHVTK-UHFFFAOYSA-N |
| Smiles | O=S(C1(C(NO)=O)CCN(CCOC)CC1)(C2=CC=C(OC3=CC=C(OC(F)(F)F)C=C3)C=C2)=O.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for SD 2590 hydrochloride
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 55.5 | 100 | |
| DMSO | 55.5 | 100 |
Preparing Stock Solutions for SD 2590 hydrochloride
The following data is based on the product molecular weight 554.96. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.8 mL | 9.01 mL | 18.02 mL |
| 5 mM | 0.36 mL | 1.8 mL | 3.6 mL |
| 10 mM | 0.18 mL | 0.9 mL | 1.8 mL |
| 50 mM | 0.04 mL | 0.18 mL | 0.36 mL |
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Product Datasheets for SD 2590 hydrochloride
References for SD 2590 hydrochloride
References are publications that support the biological activity of the product.
Becker et al (2010) Orally active MMP-1 sparing α-tetrahydropyranyl and α-piperidinyl sulfone matrix metalloproteinase (MMP) inhibitors with efficacy in cancer, arthritis, and cardiovascular disease. J.Med.Chem. 53 6653 PMID: 20726512
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Citations for SD 2590 hydrochloride
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Literature in this Area
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Angiogenesis in Cancer Poster
This poster summarizes the pathogenesis of angiogenesis in cancer, as well as some of the main angiogenesis therapeutic targets.