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Submit ReviewSDZ 205-557 hydrochloride
Description: 5-HT3 and 5-HT4 antagonist
Chemical Name: 4-Amino-5-chloro-2-methoxybenzoic acid 2-(diethylamino)ethyl ester hydrochloride
Purity: ≥99% (HPLC)
Biological Activity for SDZ 205-557 hydrochloride
SDZ 205-557 hydrochloride is a 5-HT3/5-HT4 receptor antagonist.
Technical Data for SDZ 205-557 hydrochloride
| M. Wt | 337.25 |
| Formula | C14H21ClN2O3.HCl |
| Storage | Desiccate at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 1197334-02-3 |
| PubChem ID | 11957705 |
| InChI Key | JOWUQCJWCRNVMQ-UHFFFAOYSA-N |
| Smiles | Cl.CCN(CC)CCOC(=O)C1=CC(Cl)=C(N)C=C1OC |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for SDZ 205-557 hydrochloride
References for SDZ 205-557 hydrochloride
References are publications that support the biological activity of the product.
Eglen et al (1993) The action of SDZ 205,557 at 5-hydroxytryptamine (5-HT3 and 5-HT4) receptors. Br.J.Pharmacol. 108 376 PMID: 8448587
McMahon and Cunningham (1999) Antagonism of 5-hydroxytryptamine(4) receptors attenuates hyperactivity induced by cocaine: putative role for 5-hydroxytryptamine(4) receptors in the nucleus accumbens shell. J.Pharmacol.Exp.Ther. 291 300 PMID: 10490917
Buchheit et al (1992) SDZ 205-557, a selective, surmountable antagonist for 5-HT4 receptors in the isolated guinea pig ileum. Naunyn-Schmied.Arch.Pharmacol. 345 387
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Citations for SDZ 205-557 hydrochloride
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Currently there are no citations for SDZ 205-557 hydrochloride.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
5-HT Receptors Scientific Review
Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.
Depression Poster
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.