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Submit ReviewSDZ SER 082 fumarate
Description: Selective 5-HT2B/2C antagonist
Chemical Name: (+)-cis-4,5,7a,8,9,10,11,11a-Octahydro-7H-10-methylindolo[1,7-bc][2,6]-naphthyridine fumarate
Biological Activity for SDZ SER 082 fumarate
SDZ SER 082 fumarate is a selective 5-HT2B/2C receptor antagonist with low affinity for 5-HT1A receptors. Inhibits [3H]-mesulergine binding to 5-HT2C receptors with a pKD of 7.8. Inhibits 5-HT2B mediated responses in the rat fundus (pKB = 7.34).
Licensing Information
Sold with the permission of Novartis Pharma AG
Technical Data for SDZ SER 082 fumarate
| M. Wt | 344.41 |
| Formula | C15H20N2.C4H4O4 |
| Storage | Store at RT |
| CAS Number | 1417343-80-6 |
| PubChem ID | 45073480 |
| InChI Key | DXUZZRDHJMOLTN-MRYVXRNOSA-N |
| Smiles | C(\C=C\C(O[H])=O)(O[H])=O.[H][C@@]23[C@@](CCN(C3)C)([H])CN(CC4)C1=C4C=CC=C12 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for SDZ SER 082 fumarate
References for SDZ SER 082 fumarate
References are publications that support the biological activity of the product.
Kalkman et al (1998) Cataleptogenic effect of subtype selective 5-HT receptor antagonists in the rat. Eur.J.Pharmacol. 343 201 PMID: 9570468
Mora et al (1997) Role of 5-HT2A and 5-HT2C receptor subtypes in the two types of fear generated by the elevated T-maze. Pharmacol.Biochem.Behav. 58 1051 PMID: 9408213
Nozulak et al (1995) (+)-cis 4,5,7a,8,9,10,11,11a-Octahydro-7H-10-methylindolo[1,7-bc][2,6]-naphthyridine: a 5-HT2C/2B receptor antagonist with low 5-HT2A receptor affinity. J.Med.Chem. 38 28 PMID: 7837236
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Keywords: SDZ SER 082 fumarate, SDZ SER 082 fumarate supplier, Selective, 5-HT2B/2C, antagonists, Serotonin, Receptors, SDZSER, fumarate082, SDZSER082, 5-HT2B, 5-HT2C, 1255, Tocris Bioscience
Citations for SDZ SER 082 fumarate
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
5-HT Receptors Scientific Review
Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.
Depression Poster
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.