SEW 2871

Cat. No. 2284 6 Citations Submit a Review Datasheet / COA / SDS

Pricing	Availability		Qty

Description: Cell-permeable, selective S1P₁ receptor agonist

Chemical Name: 5-[4-Phenyl-5-(trifluoromethyl)thiophen-2-yl]-3-[3-(trifluoromethyl)phenyl]1,2,4-oxadiazole

Purity: ≥99% (HPLC)

Datasheet

Citations (6)

Reviews

Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for SEW 2871

SEW 2871 is a novel, potent and selective sphingosine-1-phosphate 1 (S1P₁) receptor agonist. Activates S1P₁ receptor with an EC₅₀ of 13 nM, but does not activate S1P₂, S1P₃, S1P₄ or S1P₅ receptors at concentrations up to 10 μM. Cell-permeable and active in vivo.

Technical Data for SEW 2871

M. Wt	440.36
Formula	C₂₀H₁₀F₆N₂OS
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	256414-75-2
PubChem ID	4077460
InChI Key	OYMNPJXKQVTQTR-UHFFFAOYSA-N
Smiles	FC(F)(F)C1=C(C=C(S1)C1=NC(=NO1)C1=CC(=CC=C1)C(F)(F)F)C1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for SEW 2871

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	8.81	20
	ethanol	8.81	20

Preparing Stock Solutions for SEW 2871

The following data is based on the product molecular weight 440.36. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	11.35 mL	56.77 mL	113.54 mL
1 mM	2.27 mL	11.35 mL	22.71 mL
2 mM	1.14 mL	5.68 mL	11.35 mL
10 mM	0.23 mL	1.14 mL	2.27 mL

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Product Datasheets for SEW 2871

Certificate of Analysis / Product Datasheet

Safety Datasheet

References for SEW 2871

References are publications that support the biological activity of the product.

Hale et al (2004) A rational utilization of high-throughput screening affords selective, orally bioavailable 1-benzyl-3-carboxyazetidine sphingosine-1-phosphate-1 receptor agonists. J.Med.Chem. 47 6662 PMID: 15615513

Sanna et al (2004) Sphingosine 1-phosphate (S1P) receptor subtypes S1P₁ and S1P₃, respectively, regulate lymphocyte recirculation and heart rate. J.Biol.Chem. 279 13839 PMID: 14732717

Bolick et al (2005) Sphingosine-1-phosphate prevents tumor necrosis factor-α-mediated monocyte adhesion to aortic endothelium in mice. Arterioscler.Thromb.Vasc.Biol. 25 976 PMID: 15761190

If you know of a relevant reference for SEW 2871, please let us know.

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