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Submit ReviewSM 16
Description: Potent TGF-βRI inhibitor; orally bioavailable
Chemical Name: 4-[4-(1,3-Benzodioxol-5-yl)-5-(6-methyl-2-pyridinyl)-1H-imidazol-2-yl]bicyclo[2.2.2]octane-1-carboxamide
Purity: ≥98% (HPLC)
Biological Activity for SM 16
SM 16 is a potent TGF-β receptor type 1 (TGF-βRI) inhibitor (IC50 = 64 nM in luciferase assay). Selective for TGF-βRI over other ALK family members. Decreases Smad phosphorylation and inhibits tumor growth in a mouse xenograft model. Attenuates increased TGF-β signaling in retinal vessels of diabetic rats. Also prevents intimal thickening and vascular remodeling in rat carotid balloon injury model. Orally bioavailable.
Compound Libraries for SM 16
SM 16 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Kinase Inhibitor Library. Find out more about compound libraries available from Tocris.
Technical Data for SM 16
| M. Wt | 430.5 |
| Formula | C25H26N4O3 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 614749-78-9 |
| PubChem ID | 10387982 |
| InChI Key | JUHTXZGCTPDXRU-UHFFFAOYSA-N |
| Smiles | CC1=NC(C2=C(C3=CC=C4OCOC4=C3)NC(C56CCC(CC6)(C(N)=O)CC5)=N2)=CC=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for SM 16
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 43.05 | 100 |
Preparing Stock Solutions for SM 16
The following data is based on the product molecular weight 430.5. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.32 mL | 11.61 mL | 23.23 mL |
| 5 mM | 0.46 mL | 2.32 mL | 4.65 mL |
| 10 mM | 0.23 mL | 1.16 mL | 2.32 mL |
| 50 mM | 0.05 mL | 0.23 mL | 0.46 mL |
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Product Datasheets for SM 16
References for SM 16
References are publications that support the biological activity of the product.
Suzuki et al (2007) A novel small-molecule inhibitor of transforming growth factor β type I receptor kinase (SM16) inhibits murine mesothelioma tumor growth in vivo and prevents tumor recurrence after surgical resection. Cancer Res. 67 2351 PMID: 17332368
Fu et al (2008) SM16, an orally active TGF-β type I receptor inhibitor prevents myofibroblast induction and vascular fibrosis in the rat carotid injury model. Arterioscler.Thromb.Vasc.Biol. 28 665 PMID: 18202322
Dagher et al (2017) The increased transforming growth factor-β signaling induced by diabetes protects retinal vessels. Am.J.Pathol. 187 627 PMID: 28162229
If you know of a relevant reference for SM 16, please let us know.
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Keywords: SM 16, SM 16 supplier, SM16, TGF-beta, transforming, growth, factor, beta, inhibitors, inhibits, ALK5, ALK4, orally, bioavailable, Receptors, 6245, Tocris Bioscience
Citations for SM 16
Citations are publications that use Tocris products.
Currently there are no citations for SM 16. Do you know of a great paper that uses SM 16 from Tocris? Please let us know.
Reviews for SM 16
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Literature in this Area
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Stem Cell Research Product Guide
This product guide provides a background to the use of small molecules in stem cell research and lists over 200 products for use in:
- Self-renewal and Maintenance
- Differentiation
- Reprogramming
- Organoid Generation
- GMP and Ancillary Material Grade Products
Stem Cells Scientific Review
Written by Kirsty E. Clarke, Victoria B. Christie, Andy Whiting and Stefan A. Przyborski, this review provides an overview of the use of small molecules in the control of stem cell growth and differentiation. Key signaling pathways are highlighted, and the regulation of ES cell self-renewal and somatic cell reprogramming is discussed. Compounds available from Tocris are listed.
Stem Cells Poster
Written by Rebecca Quelch and Stefan Przyborski from Durham University (UK), this poster describes the isolation of pluripotent stem cells, their maintenance in culture, differentiation, and the generation and potential uses of organoids.
Pathways for SM 16
