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Description: Highly potent inhibitor of SARS-CoV Spike (S) protein and ACE2 interaction
Purity: ≥95% (HPLC)
Biological Activity for SP 10
SP 10 is a peptide originally derived from SARS-CoV Spike (S) protein; corresponds to amino acid residues 668 to 679. Highly potent inhibitor of SARS-CoV S protein and ACE2 interaction (IC50 = 1.88 nM in biochemical assay). Inhibits interaction of SARS-CoV S protein and Vero E6 cells in vitro.
Please note, this peptide displays 80% sequence identity to homologous site on SARS-CoV-2 S-protein (residues 689-697).
Technical Data for SP 10
| M. Wt | 1315.5 |
| Formula | C56H94N14O20S |
| Sequence | STSQKSIVAYTM |
| Storage | Store at -20°C |
| Purity | ≥95% (HPLC) |
| CAS Number | 882157-88-2 |
| PubChem ID | 11693850 |
| InChI Key | RBLTWUZIFRZOSV-SQWMWQRLSA-N |
| Smiles | O=C(N[C@@H]([C@H](O)C)C(N[C@@H](CO)C(N[C@@H](CCC(N)=O)C(N[C@@H](CCCCN)C(N[C@@H](CO)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](C(C)C)C(N[C@@H](C)C(N[C@@H](CC1=CC=C(C=C1)O)C(N[C@@H]([C@H](O)C)C(N[C@@H](CCSC)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CO)N |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for SP 10
| Solubility | Soluble to 1 mg/ml in water |
Product Datasheets for SP 10
References for SP 10
References are publications that support the biological activity of the product.
Ho et al (2006) Design and biological activities of novel inhibitory peptides for SARS-CoV spike protein and angiotensin-converting enzyme 2 interaction. Antiviral Res. 69 70 PMID: 16337697
If you know of a relevant reference for SP 10, please let us know.
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Keywords: SP 10, SP 10 supplier, SP10, SARS, CoV, spike, protein, peptide, potent, inhibitors, inhibits, ACE2, interaction, 7322, Tocris Bioscience
Citations for SP 10
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