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Submit ReviewSU 3327
Description: Selective JNK inhibitor
Alternative Names: Halicin
Chemical Name: 5-[(5-Nitro-2-thiazolyl)thio]-1,3,4thiadiazol-2-amine
Purity: ≥99% (HPLC)
Biological Activity for SU 3327
SU 3327 is a selective inhibitor of c-Jun N-terminal kinase (JNK) (IC50 = 0.7 μM). Inhibits the protein-protein interaction between JNK and JIP (IC50 = 239 nM). Displays selectivity over p38 MAPK and Akt. Restores insulin sensitivity in a mouse model of type-2 diabetes. Displays antibiotic activity against a range of bacteria including S.aureus, A.baumanni, C.difficile and M.tuberculosis.
Compound Libraries for SU 3327
SU 3327 is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Kinase Inhibitor Library and Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.
Technical Data for SU 3327
| M. Wt | 261.3 |
| Formula | C5H3N5O2S3 |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 40045-50-9 |
| PubChem ID | 11837140 |
| InChI Key | NQQBNZBOOHHVQP-UHFFFAOYSA-N |
| Smiles | NC2=NN=C(S2)SC1=NC=C([N+]([O-])=O)S1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for SU 3327
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 26.13 | 100 | |
| ethanol | 2.61 | 10 |
Preparing Stock Solutions for SU 3327
The following data is based on the product molecular weight 261.3. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.83 mL | 19.14 mL | 38.27 mL |
| 5 mM | 0.77 mL | 3.83 mL | 7.65 mL |
| 10 mM | 0.38 mL | 1.91 mL | 3.83 mL |
| 50 mM | 0.08 mL | 0.38 mL | 0.77 mL |
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Product Datasheets for SU 3327
References for SU 3327
References are publications that support the biological activity of the product.
De et al (2009) Design, synthesis and structure-activity relationship of substrate competitive, selective, and in vivo active triazole and thiadiazole inhibitors of the c-jun N-terminal kinase. J.Med.Chem. 52 1943 PMID: 19271755
Higashihira et al (2022) Halicin is effective against staphylococcus aureus biofilms in vitro. Clin.Orthop.Relat.Res. 480 1476 PMID: 35583504
If you know of a relevant reference for SU 3327, please let us know.
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Keywords: SU 3327, SU 3327 supplier, SU3327, JNK, kinases, inhibitors, inhibits, selective, MAPK, Signaling, Signalling, c-Jun, N-Terminal, SAPKs, Stress-Activated, Protein, Mitogen-Activated, Halicin, antibiotic, JNK/c-jun, Antibiotics, 3607, Tocris Bioscience
4 Citations for SU 3327
Citations are publications that use Tocris products. Selected citations for SU 3327 include:
Lo et al (2014) TNF-α induces CXCL1 chemokine expression and release in human vascular endothelial cells in vitro via two distinct signaling pathways. Acta Pharmacol Sin 35 339 PMID: 24487964
Shaw and Lloyd (2012) Post-transcriptional regulation of placenta growth factor mRNA by hydrogen peroxide. Redox Biol 84 155 PMID: 22683469
van Gent et al (2022) Synergism between the synthetic antibacterial and antibiofilm peptide (SAAP)-148 and halicin. Antibiotics (Basel) 11 673 PMID: 35625317
Jang et al (2015) Critical role of c-jun N-terminal protein kinase in promoting mitochondrial dysfunction and acute liver injury. J Biol Chem 6 552 PMID: 26491845
Do you know of a great paper that uses SU 3327 from Tocris? Please let us know.
Reviews for SU 3327
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
MAPK Signaling Scientific Review
MAP kinase signaling is integral to the regulation of numerous cellular processes such as proliferation and differentiation, and as a result is an important focus of cancer and immunology research. Updated for 2016, this review discusses the regulation of the MAPK pathway and properties of MAPK cascades. Compounds available from Tocris are listed.
Pathways for SU 3327
