Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewT16Ainh - A01
Discontinued Product
4538 has been discontinued.
View all Calcium-activated Chloride Channels products.
Description: Ca2+-activated Cl- channel transmembrane protein 16A (TMEM16A) inhibitor
Chemical Name: 2-[(5-Ethyl-1,6-dihydro-4-methyl-6-oxo-2-pyrimidinyl)thio]-N-[4-(4-methoxyphenyl)-2-thiazolyl]acetamide
Purity: ≥98% (HPLC)
Biological Activity for T16Ainh - A01
T16Ainh - A01 is an inhibitor of Ca2+-dependent Cl- channel (CaCC) transmembrane protein 16A (TMEM16A) (IC50 = 1.8 μM in A253 salivary gland epithelial cells). Inhibits EGF-induced increases in CaCC currents; blocks proliferation of tumor cells in vitro.
Technical Data for T16Ainh - A01
| M. Wt | 416.52 |
| Formula | C19H20N4O3S2 |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 552309-42-9 |
| PubChem ID | 3193184 |
| InChI Key | QSIYTNYMBWYHAA-UHFFFAOYSA-N |
| Smiles | CC1=NC(SCC(NC2=NC(C3=CC=C(OC)C=C3)=CS2)=O)=NC(O)=C1CC |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for T16Ainh - A01
References for T16Ainh - A01
References are publications that support the biological activity of the product.
Namkung et al (2011) TMEM16A inhibitors reveal TMEM16A as a minor component of calcium-activated chloride channel conductance in airway and intestinal epithelial cells. J.Biol.Chem. 286 2365 PMID: 21084298
Mroz and Keely (2012) Epidermal growth factor chronically upregulates Ca2+-dependent Cl- conductance and TMEM16A expression in intestinal epithelial cells. J.Physiol. 590 1907 PMID: 22351639
Duvvuri et al (2012) TMEM16A induces MAPK and contributes directly to tumorigenesis and cancer progression. Cancer Res. [Epub ahead of print] PMID: 22564524
View Related Products by Target
View Related Products by Product Action
Keywords: T16Ainh - A01, T16Ainh - A01 supplier, T16Ainh-A01, supplier, ca2+, calcium, activated, sensitive, chloride, Cl-, channels, CaCC, transmembrane, TMEM16A, inhibitors, inhibits, antiproliferative, antitumor, Ca2+-Activated, Chloride, Channels, 4538, Tocris Bioscience
8 Citations for T16Ainh - A01
Citations are publications that use Tocris products. Selected citations for T16Ainh - A01 include:
Bijos et al (2014) Anoctamin-1 in the juvenile rat urinary bladder. PLoS One 9 e106190 PMID: 25181534
Bill et al (2014) Small molecule-facilitated degradation of ANO1 protein: a new targeting approach for anticancer therapeutics. J Biol Chem 289 11029 PMID: 24599954
Jeon et al (2013) Presynaptic Localization and Possible Function of Calcium-Activated Chloride Channel Anoctamin 1 in the Mammalian Retina. PLoS One 8 e67989 PMID: 23840801
Kusuda et al (2019) Long-term DEX treatment diminishes store-operated Ca2+ entry in salivary acinar cells. Int J Oral Sci 11 1 PMID: 30602784
Zhang et al (2015) TMEM16A-Mediated Mucin Secretion in IL-13-Induced Nasal Epithelial Cells From Chronic Rhinosinusitis Patients. Mol Pain 7 367 PMID: 25749771
Pineda-Farias et al (2015) Role of anoctamin-1 and bestrophin-1 in spinal nerve ligation-induced neuropathic pain in rats. Cell Death Dis 11 41 PMID: 26130088
Zhang et al (2015) Anoctamin Calcium-Activated Chloride Channels May Modulate Inhibitory Transmission in the Cerebellar Cortex. PLoS One 10 e0142160 PMID: 26558388
Harper and Poole (2013) Chloride channels are necessary for full platelet phosphatidylserine exposure and procoagulant activity. PLoS One 4 e969 PMID: 24357800
Reviews for T16Ainh - A01
There are currently no reviews for this product. Be the first to review T16Ainh - A01 and earn rewards!
Have you used T16Ainh - A01?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Programmed Cell Death Poster
There are two currently recognized forms of programmed cell death: apoptosis and necroptosis. This poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.
Pathways for T16Ainh - A01
