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Description: Induces cardiomyocyte differentiation from hESCs
Chemical Name: 4-(2-(2,6-Difluorophenyl)-4-(fluorophenyl)-1H-imidazol-5-yl)pyridine
Purity: ≥98% (HPLC)
Biological Activity for TA 01
Induces cardiomyocyte differentiation from human embryonic stem cells following mesoderm induction at 1 μM. Inhibits cardiomyocyte differentiation at 5 μM. Potently inhibits CK1ε, p38α, and CK1δ (IC50 values are 6.4, 6.7 and 6.8 nM respectively).
Licensing Information
Sold under agreement from the Agency for Science, Technology and Research (A*STAR), ETPL, and affiliates including the Bioprocessing Technology Institute.
Technical Data for TA 01
| M. Wt | 351.32 |
| Formula | C20H12F3N3 |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| PubChem ID | 91691129 |
| InChI Key | TWPJJJZCYVFUOA-UHFFFAOYSA-N |
| Smiles | FC(C=C4)=CC=C4C(N=C(C3=C(F)C=CC=C3F)N2)=C2C1=CC=NC=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for TA 01
References for TA 01
References are publications that support the biological activity of the product.
Laco et al (2014) Cardiomyocyte differentiation of pluripotent stem cells with SB203580 analogues correlates with Wnt pathway CK1 inhibition independent of p38 MAPK signaling. J.Mol.Cell.Cardiol 80 56 PMID: 25528965
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1 Citation for TA 01
Citations are publications that use Tocris products. Selected citations for TA 01 include:
Laco et al (2018) Unraveling the Inconsistencies of Cardiac Differentiation Efficiency Induced by the GSK3β Inhibitor CHIR99021 in Human Pluripotent Stem Cells. Stem Cell Reports 10 1851 PMID: 29706502
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