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Tanshinone IIA

Cat. No. 4426 1 Citation Submit a Review Datasheet / COA / SDS

Discontinued Product

4426 has been discontinued.

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Description: Inhibits NF-κB and AP-1 DNA binding. Displays antioxidant properties
Chemical Name: 6,7,8,9-Tetrahydro-1,6,6-trimethylphenanthro[1,2-b]furan-10,11-dione
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Reviews
Pathways (1)
Biological Activity Technical Data Datasheets References

Biological Activity for Tanshinone IIA

Tanshinone IIA is a major tanshinone isolated from Salvia miltiorrhiza. Inhibits NF-κB and AP-1 DNA binding. Exhibits cytotoxic activity in a number of different cancer cells. Inhibits β-amyloid aggregation and protects PC12 cells from β-amyloid-induced apoptosis. Displays antioxidant and anti-inflammatory properties.

Technical Data for Tanshinone IIA

M. Wt 294.34
Formula C19H18O3
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 568-72-9
PubChem ID 164676
InChI Key HYXITZLLTYIPOF-UHFFFAOYSA-N
Smiles O=C(C1=C(C4=C3C(C)=CO4)C=CC2=C1CCCC(C)2C)C3=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for Tanshinone IIA

Certificate of Analysis / Product Datasheet
Safety Datasheet

References for Tanshinone IIA

References are publications that support the biological activity of the product.

Lee et al (2008) Anticancer effects of tanshinone I in human non-small cell lung cancer. Mol.Cancer Ther. 7 3527 PMID: 19001436

Wang et al (2007) Growth inhibition and induction of apoptosis and differentiation of tanshinone IIA in human glioma cells. J.Neurooncol. 82 11 PMID: 16955220

Jin et al (2008) Tanshinone IIA from Salvia miltiorrhiza BUNGE inhibits human aortic smooth muscle cell migration and MMP-9 activity through AKT signaling pathway. J.Cell Biochem. 104 15 PMID: 17979138

Dong et al (2012) Tanshinone IIA protects PC12 cells from β-amyloid(25-35)-induced apoptosis via PI3K/Akt signaling pathway. Mol.Biol.Rep. 39 6495 PMID: 22314911

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Keywords: Tanshinone IIA, Tanshinone IIA supplier, TanshinoneIIA, tanshinone, cytotoxic, inhibitors, inhibits, nf-kappab, nf-kb, nf-κb, ap-1, dna, binding, amyloidbeta, amyloidb, amyloidβ, Antioxidants, NF-kB/IkB, Amyloid, Beta, Peptides, 4426, Tocris Bioscience

1 Citation for Tanshinone IIA

Citations are publications that use Tocris products. Selected citations for Tanshinone IIA include:

Pedersen et al (2012) RAC1 in keratinocytes regulates crosstalk to immune cells by Arp2/3-dependent control of STAT1. J Cell Sci 125 5379 PMID: 22956547

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Pathways for Tanshinone IIA

NF-κB Signaling Pathway

NF-κB Signaling Pathway

NF-κB signaling plays an important role in inflammation, the innate and adaptive immune response and stress. Dysregulated signaling can occur in inflammatory and autoimmune diseases.