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Description: ADAM-17 (TACE) and MMP inhibitor
Chemical Name: N-[(2R)-2-[2-(Hydroxyamino)-2-oxoethyl]-4-methyl-1-oxopentyl]-3-(2-naphthalenyl)--alanyl-L-alaninamide
Purity: ≥95% (HPLC)
Biological Activity for TAPI 1
TAPI 1 is a TACE/ADAM-17 and MMP inhibitor. Blocks shedding of TNF from cell membranes. Reduces pain-associated behavior in mice with a constructive mononeuropathy.
This product is typically reconstituted in DMSO.
Technical Data for TAPI 1
| M. Wt | 499.6 |
| Formula | C26H37N5O5 |
| Storage | Store at -20°C |
| Purity | ≥95% (HPLC) |
| CAS Number | 163847-77-6 |
| PubChem ID | 9827273 |
| InChI Key | AWNBSWDIOCXWJW-OWHMDLSXSA-N |
| Smiles | ONC(C[C@@H](CC(C)C)C(N[C@@H](CC1=CC(C=CC=C2)=C2C=C1)C(N[C@@H](C)C(NCCN)=O)=O)=O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for TAPI 1
References for TAPI 1
References are publications that support the biological activity of the product.
Sommer et al (1997) A metalloprotease-inhibitor reduces pain associated behavior in mice with experimental neuropathy. Neurosci. Lett. 237 45 PMID: 9406876
Mohler et al (1994) Protection against a lethal dose of endotoxin by an inhibitor of tumour necrosis factor processing. Nature 370 218 PMID: 8028669
If you know of a relevant reference for TAPI 1, please let us know.
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Keywords: TAPI 1, TAPI 1 supplier, TAPI1, ADAM17, metalloproteases, MMPs, metalloproteinases, inhibits, inhibitors, adams, TNFa, TNFα, converting, enzyme, TACE, ADAMs, Matrix, Metalloprotease, 6162, Tocris Bioscience
1 Citation for TAPI 1
Citations are publications that use Tocris products. Selected citations for TAPI 1 include:
Franck et al (2020) Localized Intercellular Transfer of Ephrin-As by Trans-endocytosis Enables Long-Term Signaling. Dev Cell 52 104-117.e5 PMID: 31866204
Do you know of a great paper that uses TAPI 1 from Tocris? Please let us know.
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