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Discontinued Product
4898 has been discontinued.
Description: γ-secretase modulator; reduces Aβ42 levels
Chemical Name: 6-[(4-Fluorophenyl)(4-methyl-1-piperidinyl)methyl]-a-methyl-4'-(trifluoromethyl)-[1,1'-biphenyl]-3-acetic acid
Purity: ≥98% (HPLC)
Biological Activity for TC-E 5006
TC-E 5006 is a γ-secretase modulator. Reduces Aβ42 levels in vitro (EC50 = 390 nM) and in vivo. Orally bioavailable.
Technical Data for TC-E 5006
| M. Wt | 499.54 |
| Formula | C29H29F4NO2 |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1257395-14-4 |
| PubChem ID | 68414868 |
| InChI Key | ONYWALXTZFPKAS-UHFFFAOYSA-N |
| Smiles | CC(CC1)CCN1C(C2=C(C3=CC=C(C(F)(F)F)C=C3)C=C(C(C)C(O)=O)C=C2)C4=CC=C(F)C=C4 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for TC-E 5006
References for TC-E 5006
References are publications that support the biological activity of the product.
Peng et al (2011) Discovery of BIIB042, a potent, selective, and orally bioavailable γ-secretase modulator. ACS Med.Chem.Lett. 2 786 PMID: 24900267
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Keywords: TC-E 5006, TC-E 5006 supplier, TC-E5006, biib042, γ-secretase, g-secretase, gamma-secretase, modulators, Aβ42, AB42, Abeta42, amyloid, Gamma-Secretase, 4898, Tocris Bioscience
Citations for TC-E 5006
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Currently there are no citations for TC-E 5006.
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