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TL 13-27

Cat. No. 6525 Submit a Review Datasheet / COA / SDS
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Description: Negative control for TL 12-186 (Cat. No. 6524)
Chemical Name: N-(2-(2-(2-(4-(4-((5-Chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)phenyl)piperazin-1-yl)ethoxy)ethoxy)ethyl)-2-((1,3-dioxo-2-(2-oxopiperidin-3-yl)isoindolin-4-yl)amino)acetamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (2)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for TL 13-27

TL 13-27 is a negative control for TL 12-186 (Cat. No. 6524). Demonstrates no kinase degradation in vitro.

Technical Data for TL 13-27

M. Wt 917.48
Formula C44H53ClN10O8S
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 2250025-90-0
PubChem ID 134812844
InChI Key DOOUFCVVMSZNOA-UHFFFAOYSA-N
Smiles O=C1C(CCCN1)N2C(C3=C(C2=O)C=CC=C3NCC(NCCOCCOCCN4CCN(CC4)C5=CC=C(C=C5)NC6=NC(NC7=C(C=CC=C7)S(=O)(C(C)C)=O)=C(C=N6)Cl)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for TL 13-27

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 91.75 100

Preparing Stock Solutions for TL 13-27

The following data is based on the product molecular weight 917.48. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.09 mL 5.45 mL 10.9 mL
5 mM 0.22 mL 1.09 mL 2.18 mL
10 mM 0.11 mL 0.54 mL 1.09 mL
50 mM 0.02 mL 0.11 mL 0.22 mL

Molarity Calculator

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

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Dilution Calculator

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References for TL 13-27

References are publications that support the biological activity of the product.

Huang et al (2018) A chemoproteomic approach to query the degradable kinome using a multi-kinase degrader. Cell Chem.Biol. 25 88 PMID: 29129717

If you know of a relevant reference for TL 13-27, please let us know.

View Related Products by Target

Keywords: TL 13-27, TL 13-27 supplier, TL13-27, PROTAC, PROTACs, Proteolysis, targeted, chimeras, cereblon, E3, ubiquitin, ligase, kinase, inhibitors, degraders, negative, controls, Other, Kinases, Negative, Controls, 6525, Tocris Bioscience

Citations for TL 13-27

Citations are publications that use Tocris products.

Currently there are no citations for TL 13-27. Do you know of a great paper that uses TL 13-27 from Tocris? Please let us know.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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TPD and Induced Proximity Research Product Guide

TPD and Induced Proximity Research Product Guide

This brochure highlights the tools and services available from Bio-Techne to support your Targeted Protein Degradation and Induced Proximity research, including:

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Targeted Protein Degradation Poster

Targeted Protein Degradation Poster

Degraders (e.g. PROTACs) are bifunctional small molecules, that harness the Ubiquitin Proteasome System (UPS) to selectively degrade target proteins within cells. They consist of three covalently linked components: an E3 ubiquitin ligase ligand, a linker and a ligand for the target protein of interest. Authored in-house, this poster outlines the generation of a toolbox of building blocks for the development of Degraders. The characteristics and selection of each of these components are discussed. Presented at EFMC 2018, Ljubljana, Slovenia