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Submit Reviewtri-GalNAc-C5-AF647
Description: Fluorescent ASGPR ligand. Application: flow cytometry, fluorescence microscopy
Purity: ≥90%
Biological Activity for tri-GalNAc-C5-AF647
Key information: tri-GalNAc-C5-AF647 is a fluorescent asialoglycoprotein receptor (ASGPR) ligand. Suitable for live-cell imaging. Can be used for lysosomal uptake imaging in live cells. Also can be used for isolating hepatocytes due to its uptake via ASGPR receptor.
Application: Flow cytometry, fluorescence microscopy.
Properties and Photophysical Data: Suitable for multiplexing and can be combined with DAPI (Cat. No. 5748) counter-staining. Excitation and emission maxima (λ) are 663 and 684 nm, respectively.
Optical Data for tri-GalNAc-C5-AF647
| λabs | 663 nm |
|---|---|
| λem | 684 nm |
| Cell Permeable | Yes |
| Application | Flow Cytometry, Fluorescence Microscopy |
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Use our spectra viewer to interactively plan your experiments, assessing multiplexing options. View the excitation and emission spectra for our fluorescent dye range and other commonly used dyes.
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Technical Data for tri-GalNAc-C5-AF647
| M. Wt | 2456.74 |
| Formula | C103H162N16O44S4 |
| Storage | Store at -20°C |
| Purity | ≥90% |
| InChI Key | YADZNIHLQXJZAN-PPECRGGSSA-N |
| Smiles | O=C(NC(COCC1=CN(N=N1)CCOCCOCCOCCO[C@H]2O[C@H]([C@@H](O)[C@@H](O)[C@@H]2NC(C)=O)CO)(COCC3=CN(N=N3)CCOCCOCCOCCO[C@@H]4O[C@@H]([C@H](O)[C@H](O)[C@H]4NC(C)=O)CO)COCC5=CN(N=N5)CCOCCOCCOCCO[C@H]6O[C@H]([C@@H](O)[C@@H](O)[C@@H]6NC(C)=O)CO)CCCCCNC(CCCCCC7(C(/C=C/C=C/C=C8C(C)(C9=C(N\8CCCS(=O)(O)=O)C=CC(S(=O)(O)=O)=C9)C)=[N+](C%10=C7C=C(C=C%10)S(=O)(O)=O)CCCS(=O)([O-])=O)C)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for tri-GalNAc-C5-AF647
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 24.57 | 10 |
Preparing Stock Solutions for tri-GalNAc-C5-AF647
The following data is based on the product molecular weight 2456.74. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 4.07 mL | 20.35 mL | 40.7 mL |
| 0.5 mM | 0.81 mL | 4.07 mL | 8.14 mL |
| 1 mM | 0.41 mL | 2.04 mL | 4.07 mL |
| 5 mM | 0.08 mL | 0.41 mL | 0.81 mL |
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Product Datasheets for tri-GalNAc-C5-AF647
References for tri-GalNAc-C5-AF647
References are publications that support the biological activity of the product.
Sanhueza et al (2017) Efficient liver targeting by polyvalent display of a compact ligand for the asialoglycoprotein receptor. J.Am.Chem.Soc. 139 3528 PMID: 28230359
If you know of a relevant reference for tri-GalNAc-C5-AF647, please let us know.
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Citations for tri-GalNAc-C5-AF647
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