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Submit ReviewU-54494A hydrochloride
Discontinued Product
0498 has been discontinued.
Description: κ agonist
Chemical Name: cis-(±)-3,4-Dichloro-N-methyl-N-[2-(1-pyrrolidinyl)cyclohexyl]benzamide hydrochloride
Biological Activity for U-54494A hydrochloride
κ-opioid agonist and anticonvulsant. Perhaps acts as an NMDA antagonist.
Technical Data for U-54494A hydrochloride
| M. Wt | 391.77 |
| Formula | C18H24Cl2N2O.HCl |
| Storage | Store at RT |
| CAS Number | 112465-94-8 |
| PubChem ID | 183470 |
| InChI Key | JUBNVWGVNWIXMB-SJORKVTESA-N |
| Smiles | O=C(C3=CC(Cl)=C(Cl)C=C3)N([C@H]1[C@@H](N2CCCC2)CCCC1)C |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for U-54494A hydrochloride
Certificate of Analysis is currently unavailable on-line.
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References for U-54494A hydrochloride
References are publications that support the biological activity of the product.
Proietti et al (1991) In vitro depressant effects of U-54494A, an anticonvulsant related to kappa opioids in the hippocampus. Neuropharmacology 30 637 PMID: 1656303
Sethy and Sage (1992) Modulation of release of acetylcholine from the striatum by a proposed excitatory amino acid antagonist U-54494A: comparison with known antagonists, D.pam and phen. Neuropharmacology 31 111 PMID: 1348110
Voigtlander et al (1987) U-54494A: a unique anticonvulsant related to kappa opioid agonists. J.Pharmacol.Exp.Ther. 243 542 PMID: 2824750
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Keywords: U-54494A hydrochloride, U-54494A hydrochloride supplier, agonists, κ-opioid, kappa-opioid, KOP, Receptors, OP2, Kappa, Opioid, 0498, Tocris Bioscience
Citations for U-54494A hydrochloride
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Currently there are no citations for U-54494A hydrochloride.
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