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Description: Potent and selective MMP-3 inhibitor
Chemical Name: N1-[(1S)-2,2-Dimethyl-1-[[[(1R)-1-phenylethyl]amino]carbonyl]propyl]-N4-hydroxy-2-[3-(2-methyl[1,1'-biphenyl]-4-yl)propyl]-butanediamine
Purity: ≥95% (HPLC)
Biological Activity for UK 356618
UK 356618 is a potent and selective inhibitor of MMP-3 (IC50 = 5.9 nM). Displays selectivity over a range of MMPs (IC50 values are 73, 840, 1790, 1900 and 51000 for MMP-13, MMP-9, MMP-2, MMP-14 and MMP-1 respectively).
Licensing Information
Sold for research purposes under agreement from Pfizer Inc.
Technical Data for UK 356618
| M. Wt | 557.72 |
| Formula | C34H43N3O4 |
| Storage | Store at -20°C |
| Purity | ≥95% (HPLC) |
| CAS Number | 230961-08-7 |
| PubChem ID | 10370504 |
| InChI Key | JJHRUUKMPWUYIB-HVOSOHGQSA-N |
| Smiles | CC1=C(C2=CC=CC=C2)C=CC(CCC[C@H](CC(NO)=O)C(N[C@H]([C@@](N[C@H](C)C3=CC=CC=C3)=O)C(C)(C)C)=O)=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for UK 356618
References for UK 356618
References are publications that support the biological activity of the product.
Fray and Dickinson (2001) Discovery of potent and selective succinyl hydroxamate inhibitors of matrix metalloprotease-3 (stromelysin-1). Bioorg.Med.Chem.Lett. 11 571 PMID: 11229774
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Keywords: UK 356618, UK 356618 supplier, pfizer, UK356618, matrix, metalloprotease, mmp, selective, inhibitors, inhibits, mmp-3, stromelysin, 1, progelatinase, metalloproteinase, Matrix, Metalloprotease, 4187, Tocris Bioscience
1 Citation for UK 356618
Citations are publications that use Tocris products. Selected citations for UK 356618 include:
Lee et al (2014) Nestin depletion induces melanoma matrix metalloproteinases and invasion. Lab Invest 94 1382 PMID: 25365206
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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Angiogenesis in Cancer Poster
This poster summarizes the pathogenesis of angiogenesis in cancer, as well as some of the main angiogenesis therapeutic targets.