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UK 383367

Cat. No. 4188 1 Citation Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: Potent and selective BMP-1 (PCP) inhibitor
Chemical Name: 3-(Aminocarbonyl)-β-(3-cyclohexylpropyl)-N-hydroxy-1,2,4-oxadiazole-5-propanamide
Purity: ≥99% (HPLC)
Datasheet
Citations (1)
Reviews
Literature (1)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for UK 383367

UK 383367 is a potent and selective inhibitor of BMP-1 (procollagen C-proteinase; PCP) (IC50 = 44 nM). Selective for BMP-1 over MMPs 1, 2, 3, 9 and 14 (IC50 values are >10,000 nM for listed MMPs).

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Compound Libraries for UK 383367

UK 383367 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for UK 383367

M. Wt 324.38
Formula C15H24N4O4
Storage Store at -20°C
Purity ≥99% (HPLC)
CAS Number 348622-88-8
PubChem ID 9818682
InChI Key ARJCBSRIPGJMAD-LLVKDONJSA-N
Smiles ONC(C[C@H](C2=NC(C(N)=O)=NO2)CCCC1CCCCC1)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for UK 383367

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 32.44 100

Preparing Stock Solutions for UK 383367

The following data is based on the product molecular weight 324.38. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.08 mL 15.41 mL 30.83 mL
5 mM 0.62 mL 3.08 mL 6.17 mL
10 mM 0.31 mL 1.54 mL 3.08 mL
50 mM 0.06 mL 0.31 mL 0.62 mL

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References for UK 383367

References are publications that support the biological activity of the product.

Allan et al (2006) Pharmacokinetics and metabolism of UK-383,367 in rats and dogs: a rationale for long-lived plasma radioactivity. Xenobiotica 36 399 PMID: 16854779

Fish et al (2007) Potent and selective nonpeptidic inhibitors of procollagen C-proteinase. J.Med.Chem. 50 3442 PMID: 17591762

Bailey et al (2008) Succinyl hydroxamates as potent and selective non-peptidic inhibitors of procollagen C-proteinase: design, synthesis, and evaluation as topically applied, dermal anti-scarring agents. Bioorg.Med.Chem.Lett. 18 6562 PMID: 18945617

If you know of a relevant reference for UK 383367, please let us know.

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Keywords: UK 383367, UK 383367 supplier, pfizer, UK383367, procollagen, c, proteinase, BMP-1, bone, morphogenic, morphogenetic, proteins, inhibitors, inhibits, Matrix, Metalloprotease, 4188, Tocris Bioscience

1 Citation for UK 383367

Citations are publications that use Tocris products. Selected citations for UK 383367 include:

Hays et al (2018) Vascular smooth muscle cells direct extracellular dysregulation in aortic stiffening of hypertensive rats. Aging Cell 17 e12748 PMID: 29603864

Do you know of a great paper that uses UK 383367 from Tocris? Please let us know.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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