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Submit ReviewVialinin A is an inhibitor of ubiquitin-specific peptidase 4 (USP4), USP5/isopeptidase T (IsoT) and UCH-L1 deubiquitinating enzyme (DUB) activity (IC50 values are 1.5, 5.9 and 22.3 μM, respectively). Shows no significant inhibition of UCH-L3, USP2, and USP8 activities. Decreases release of TNF-α (IC50 = 0.09 nM) from RBL-2H3 mast cells. Displays anticancer activity decreasing viability in human colonic carcinoma cells. Inhibits VEGF-induced growth and proliferation of HUVECs and production of ROS, cytokines and chemokines in vitro. Also inhibits neovasularization in a mouse model.
M. Wt | 562.57 |
Formula | C34H26O8 |
Storage | Store at -20°C |
Purity | ≥98% (HPLC) |
CAS Number | 858134-23-3 |
PubChem ID | 11563133 |
InChI Key | NOJUKCRPSUMHQQ-UHFFFAOYSA-N |
Smiles | OC(C(O)=C(C3=CC=C(O)C=C3)C(OC(CC4=CC=CC=C4)=O)=C2OC(CC5=CC=CC=C5)=O)=C2C1=CC=C(O)C=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
References are publications that support the biological activity of the product.
Norikura et al (2011) Anticancer activities of thelephantin O and vialinin A isolated from Thelephora aurantiotincta. J.Agric.Food Chem. 59 6974 PMID: 21630659
Okada et al (2013) Vialinin A is a ubiquitin-specific peptidase inhibitor. Bioorg.Med.Chem.Lett. 23 4328 PMID: 23791076
Onose et al (2012) Inhibitory effects of vialinin A and its analog on tumor necrosis factor-α release and production from RBL-2H3 cells. Cell Immunol. 279 140 PMID: 23246504
Sonowal et al (2018) Vialinin A, an edible mushroom-derived p-terphenyl antioxidant, prevents VEGF-induced neovascularization in vitro and in vivo. Oxid Med Cell Longev 1052102 PMID: 29541344
Keywords: Vialinin A, Vialinin A supplier, inhibitors, inhibits, ubquitin, ubquitination, ubiquitin-specific, peptidase, 4, USP4, USP5, isopeptidase, T, IsoT, UCH-L1, deubiquitinating, enzymes, DUB, TNF-a, TNF-alpha, TNF, anticancer, angiogenesis, antioxidant, nevasularization, Deubiquitinating, Enzymes, Antiangiogenics, 4988, Tocris Bioscience
Citations are publications that use Tocris products. Selected citations for Vialinin A include:
Lin et al (2017) USP4 interacts and positively regulates IRF8 function via K48-linked deubiquitination in regulatory T cells. FEBS Lett 591 1677 PMID: 28477415
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