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VU 0071063

Cat. No. 7057 Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: Selective activator of SUR1 Kir6.2 channels
Chemical Name: 7-[[4-(1,1-Dimethylethyl)phenyl]methyl]-3,7-dihydro-1,3-dimethyl-1H-purine-2,6-dione
Purity: ≥98% (HPLC)
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Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for VU 0071063

VU 0071063 is a selective activator of SUR1 Kir6.2 channels and pancreatic β-cell KATP channels (EC50 = 7 μM and 0.3-10.3 μM, respectively). VU 0071063 inhibits insulin secretion in pancreatic β-cells by inducing hyperpolarization of β-cell membranes and reduces voltage-dependent calcium channel activation and Ca2+ influx. VU 0071063 is active in vivo and brain penetrant.

Technical Data for VU 0071063

M. Wt 326.4
Formula C18H22N4O2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 333415-38-6
PubChem ID 590142
InChI Key ZFZAIHKQJBMYLO-UHFFFAOYSA-N
Smiles CC(C)(C1=CC=C(CN2C=NC3=C2C(N(C)C(N3C)=O)=O)C=C1)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for VU 0071063

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 1.63 5

Preparing Stock Solutions for VU 0071063

The following data is based on the product molecular weight 326.4. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.05 mM 61.27 mL 306.37 mL 612.75 mL
0.25 mM 12.25 mL 61.27 mL 122.55 mL
0.5 mM 6.13 mL 30.64 mL 61.27 mL
2.5 mM 1.23 mL 6.13 mL 12.25 mL

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References for VU 0071063

References are publications that support the biological activity of the product.

Raphemot et al (2014) Direct activation of β-cell KATP channels with a novel xanthine derivative. Mol.Pharmacol. 85 858 PMID: 24646456

Kharade et al (2019) Structure-activity relationships, pharmacokinetics, and pharmacodynamics of the Kir6.2/SUR1-specific channel opener VU0071063. J.Pharmacol.Exp.Ther. 370 350 PMID: 31201216

If you know of a relevant reference for VU 0071063, please let us know.

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Citations for VU 0071063

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