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Submit ReviewVU 0134992
Description: Kir4.1 blocker
Chemical Name: 2-(2-Bromo-4-isopropylphenoxy)-N-(2,2,6,6-tetramethylpiperidin-4-yl)acetamide
Purity: ≥98% (HPLC)
Biological Activity for VU 0134992
VU 0134992 is a Kir4.1 potassium channel blocker (IC50 = 0.97 μM). Displays 10-fold selectivity for Kir4.1 over Kir4.1/5.1 concatemeric channels and >30-fold selectivity over Kir1.1, 2.1 and 2.2. Increases urine output and urinary Na+ and K+ excretion in volume-loaded rats.
Compound Libraries for VU 0134992
VU 0134992 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for VU 0134992
| M. Wt | 411.38 |
| Formula | C20H31BrN2O2 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 755002-90-5 |
| PubChem ID | 1319582 |
| InChI Key | OTTDLWFVHQYRDA-UHFFFAOYSA-N |
| Smiles | CC(C)C1=CC(Br)=C(OCC(=O)NC2CC(C)(C)NC(C)(C)C2)C=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for VU 0134992
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 41.14 | 100 | |
| ethanol | 41.14 | 100 |
Preparing Stock Solutions for VU 0134992
The following data is based on the product molecular weight 411.38. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.43 mL | 12.15 mL | 24.31 mL |
| 5 mM | 0.49 mL | 2.43 mL | 4.86 mL |
| 10 mM | 0.24 mL | 1.22 mL | 2.43 mL |
| 50 mM | 0.05 mL | 0.24 mL | 0.49 mL |
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Product Datasheets for VU 0134992
References for VU 0134992
References are publications that support the biological activity of the product.
Kharade et al (2018) Discovery, characterization, and effects on renal fluid and electrolyte excretion of the Kir4.1 potassium channel pore blocker, VU0134992. Mol.Pharmacol. 94 926 PMID: 29895592
If you know of a relevant reference for VU 0134992, please let us know.
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Keywords: VU 0134992, VU 0134992 supplier, VU0134992, inwardly, rectifying, inward, rectifier, potassium, channel, Kir, blocker, inhibitor, inhibits, Kir4.1, Inward, Potassium, Channels, 6877, Tocris Bioscience
2 Citations for VU 0134992
Citations are publications that use Tocris products. Selected citations for VU 0134992 include:
Naoki et al (2023) Detection of astrocytic slow oscillatory activity and response to seizurogenic compounds using planar microelectrode array. Front Neurosci 16 1050150 PMID: 36703996
Christoph et al (2022) Induction of Survival of Motor Neuron (SMN) Protein Deficiency in Spinal Astrocytes by Small Interfering RNA as an In Vitro Model of Spinal Muscular Atrophy. Cells 11 PMID: 35159369
Do you know of a great paper that uses VU 0134992 from Tocris? Please let us know.
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