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Submit ReviewWM 1119
Description: High affinity KAT6A (MOZ) competitive inhibitor
Chemical Name: 2-Fluoro-N'-(3-fluoro-5-(pyridin-2-yl)benzoyl)benzenesulfonohydrazide
Purity: ≥98% (HPLC)
Biological Activity for WM 1119
WM 1119 is a high affinity and competitive lysine acetyltransferase 6A (KAT6A/MOZ) inhibitor (Kd = 2 nM), which displays >250-fold affinity for KAT6A compared to KAT5 and KAT7. WM 1119 induces cell-cycle exit and cellular senescence, and inhibits growth of B-cell lymphoma cells in vitro (IC50 = 0.25 μM). WM 1119 also reduces H3K9ac in tumor cells, and decreases tumor burden and spleen weight in a mouse lymphoma model.
Licensing Information
Sold under license from Monash University
External Portal Information for WM 1119
Chemicalprobes.org and the Chemical Probes webpages of the Structural Genomics Consortium are portals that offer independent guidance on the selection and/or application of small molecules for research. The use of WM 1119 is reviewed on chemicalprobes.org and the SGC website.
Compound Libraries for WM 1119
WM 1119 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Epigenetics Library. Find out more about compound libraries available from Tocris.
Technical Data for WM 1119
| M. Wt | 389.38 |
| Formula | C18H13F2N3O3S |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 2055397-28-7 |
| PubChem ID | 133080719 |
| InChI Key | QLXULUNLCRKWRD-UHFFFAOYSA-N |
| Smiles | FC1=CC(C2=CC=CC=N2)=CC(C(NNS(=O)(C3=C(C=CC=C3)F)=O)=O)=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for WM 1119
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 38.94 | 100 |
Preparing Stock Solutions for WM 1119
The following data is based on the product molecular weight 389.38. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.57 mL | 12.84 mL | 25.68 mL |
| 5 mM | 0.51 mL | 2.57 mL | 5.14 mL |
| 10 mM | 0.26 mL | 1.28 mL | 2.57 mL |
| 50 mM | 0.05 mL | 0.26 mL | 0.51 mL |
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Product Datasheets for WM 1119
References for WM 1119
References are publications that support the biological activity of the product.
Baell et al (2018) Inhibitors of histone acetyltransferases KAT6A/B induce senescence and arrest tumour growth. Nature. 560 253 PMID: 30069049
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Keywords: WM 1119, WM 1119 supplier, WM1119, KAT6A, KAT, 6A, MOZ, inhibitors, inhibits, competitive, high, affinity, lysine, histone, acetyltransferase, HAT, Histone, Acetyltransferases, 6692, Tocris Bioscience
1 Citation for WM 1119
Citations are publications that use Tocris products. Selected citations for WM 1119 include:
Jun et al (2020) High-performance CRISPR-Cas12a genome editing for combinatorial genetic screening. Nat Commun 11 3455 PMID: 32661245
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Reviews for WM 1119
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Epigenetics Scientific Review
Written by Susanne Müller-Knapp and Peter J. Brown, this review gives an overview of the development of chemical probes for epigenetic targets, as well as the impact of these tool compounds being made available to the scientific community. In addition, their biological effects are also discussed. Epigenetic compounds available from Tocris are listed.