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Submit ReviewWM 3835 is a lysine acetyltransferase HBO1 (KAT7) inhibitor. Reduces H3K14ac levels and inhibits growth and viability of acute myeloid leukemia cell lines in vitro. Cell-permeable.
WM 3835 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Epigenetics Library. Find out more about compound libraries available from Tocris.
M. Wt | 400.42 |
Formula | C20H17FN2O4S |
Storage | Store at -20°C |
Purity | ≥98% (HPLC) |
CAS Number | 2229025-70-9 |
PubChem ID | 134581412 |
InChI Key | KVJFJJXCBRSCDY-UHFFFAOYSA-N |
Smiles | CC1=CC(C2=CC=CC=C2)=CC(C(NNS(=O)(C3=CC(O)=CC=C3)=O)=O)=C1F |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solvent | Max Conc. mg/mL | Max Conc. mM | |
---|---|---|---|
Solubility | |||
DMSO | 40.04 | 100 | |
ethanol | 20.02 | 50 |
The following data is based on the product molecular weight 400.42. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 2.5 mL | 12.49 mL | 24.97 mL |
5 mM | 0.5 mL | 2.5 mL | 4.99 mL |
10 mM | 0.25 mL | 1.25 mL | 2.5 mL |
50 mM | 0.05 mL | 0.25 mL | 0.5 mL |
References are publications that support the biological activity of the product.
MacPherson et al (2019) HBO1 is required for the maintenance of leukaemia stem cells. Nature 577 299 PMID: 31827282
If you know of a relevant reference for WM 3835, please let us know.
Keywords: WM 3835, WM 3835 supplier, WM3835, Lysine, acetyl, transferase, inhibitors, inhibits, KAT7, HBO1, histone, HATs, MYST2, Histone, Acetyltransferases, 7366, Tocris Bioscience
Citations are publications that use Tocris products. Selected citations for WM 3835 include:
Lancho et al (2023) A therapeutically targetable NOTCH1-SIRT1-KAT7 axis in T-cell leukemia. Blood Cancer Discov. 4 12 PMID: 36322781
Do you know of a great paper that uses WM 3835 from Tocris? Please let us know.
Average Rating: 5 (Based on 1 Review.)
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Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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Written by Susanne Müller-Knapp and Peter J. Brown, this review gives an overview of the development of chemical probes for epigenetic targets, as well as the impact of these tool compounds being made available to the scientific community. In addition, their biological effects are also discussed. Epigenetic compounds available from Tocris are listed.