WM 3835

Pricing Availability   Qty
Description: Lysine acetyltransferase HBO1 (KAT7) inhibitor
Chemical Name: N'-(4-Fluoro-5-methyl-[1,1'-biphenyl]-3-carbonyl)-3-hydroxybenzenesulfonohydrazide
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Reviews (1)
Literature (1)

Biological Activity for WM 3835

WM 3835 is a lysine acetyltransferase HBO1 (KAT7) inhibitor. Reduces H3K14ac levels and inhibits growth and viability of acute myeloid leukemia cell lines in vitro. Cell-permeable.

Compound Libraries for WM 3835

WM 3835 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Epigenetics Library. Find out more about compound libraries available from Tocris.

Technical Data for WM 3835

M. Wt 400.42
Formula C20H17FN2O4S
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 2229025-70-9
PubChem ID 134581412
InChI Key KVJFJJXCBRSCDY-UHFFFAOYSA-N
Smiles CC1=CC(C2=CC=CC=C2)=CC(C(NNS(=O)(C3=CC(O)=CC=C3)=O)=O)=C1F

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for WM 3835

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 40.04 100
ethanol 20.02 50

Preparing Stock Solutions for WM 3835

The following data is based on the product molecular weight 400.42. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.5 mL 12.49 mL 24.97 mL
5 mM 0.5 mL 2.5 mL 4.99 mL
10 mM 0.25 mL 1.25 mL 2.5 mL
50 mM 0.05 mL 0.25 mL 0.5 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

References for WM 3835

References are publications that support the biological activity of the product.

MacPherson et al (2019) HBO1 is required for the maintenance of leukaemia stem cells. Nature 577 299 PMID: 31827282


If you know of a relevant reference for WM 3835, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Histone Acetyltransferase Inhibitors

Keywords: WM 3835, WM 3835 supplier, WM3835, Lysine, acetyl, transferase, inhibitors, inhibits, KAT7, HBO1, histone, HATs, MYST2, Histone, Acetyltransferases, 7366, Tocris Bioscience

1 Citation for WM 3835

Citations are publications that use Tocris products. Selected citations for WM 3835 include:

Lancho et al (2023) A therapeutically targetable NOTCH1-SIRT1-KAT7 axis in T-cell leukemia. Blood Cancer Discov. 4 12 PMID: 36322781


Do you know of a great paper that uses WM 3835 from Tocris? Please let us know.

Reviews for WM 3835

Average Rating: 5 (Based on 1 Review.)

5 Star
100%
4 Star
0%
3 Star
0%
2 Star
0%
1 Star
0%

Have you used WM 3835?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Filter by:


Block Hbo1.
By Anonymous on 11/15/2024
Assay Type: In Vivo
Species: Mouse
Cell Line/Tissue: mouse brain

10mg/kg injection to mice for 10 days

We test Hbo1 inhibitor using HBO1 western blot. First lane is ctrl group. Lane 2 and 3 are WM 3835 injection groups.

review image

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Epigenetics Scientific Review

Epigenetics Scientific Review

Written by Susanne Müller-Knapp and Peter J. Brown, this review gives an overview of the development of chemical probes for epigenetic targets, as well as the impact of these tool compounds being made available to the scientific community. In addition, their biological effects are also discussed. Epigenetic compounds available from Tocris are listed.