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Submit ReviewWM 8014
Description: Potent and selective KAT6A and KAT6B inhibitor
Chemical Name: N'-(4-Fluoro-5-methyl-[1,1'-biphenyl]-3-carbonyl)benzenesulfonohydrazide
Purity: ≥98% (HPLC)
Biological Activity for WM 8014
WM 8014 is a potent and selective lysine acetyltransferase KAT6A and KAT6B inhibitor (IC50 values are 8 and 28 nM, respectively). Exhibits > 10-fold selectivity for KAT6A/B over KAT7 and KAT5, and no significant activity against KAT8, KAT2A/2B, and KAT3A/B. Induces cell cycle arrest in G1/G0 in MEFs and inhibits proliferation of lymphoma cells in vitro. Cell permeant. Suitable for use in vitro.
Licensing Information
Sold under license from Monash University
Compound Libraries for WM 8014
WM 8014 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Epigenetics Library. Find out more about compound libraries available from Tocris.
Technical Data for WM 8014
| M. Wt | 384.42 |
| Formula | C20H17FN2O3S |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 2055397-18-5 |
| PubChem ID | 133053564 |
| InChI Key | PHHZKBMVRPULAW-UHFFFAOYSA-N |
| Smiles | CC1=CC(C2=CC=CC=C2)=CC(C(NNS(=O)(C3=CC=CC=C3)=O)=O)=C1F |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for WM 8014
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 7.69 | 20 | |
| ethanol | 3.84 | 10 |
Preparing Stock Solutions for WM 8014
The following data is based on the product molecular weight 384.42. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.2 mM | 13.01 mL | 65.03 mL | 130.07 mL |
| 1 mM | 2.6 mL | 13.01 mL | 26.01 mL |
| 2 mM | 1.3 mL | 6.5 mL | 13.01 mL |
| 10 mM | 0.26 mL | 1.3 mL | 2.6 mL |
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Product Datasheets for WM 8014
References for WM 8014
References are publications that support the biological activity of the product.
Baell et al (2018) Inhibitors of histone acetyltransferases KAT6A/B induce senescence and arrest tumour growth. Nature 560 253 PMID: 30069049
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Keywords: WM 8014, WM 8014 supplier, WM8014, potent, selective, KAT6A, KAT6B, inhibitors, inhibits, histone, lysine, acetyltransferase, MOZ, MYST3, in, vitro, HAT, Histone, Acetyltransferases, 6693, Tocris Bioscience
Citations for WM 8014
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Epigenetics Scientific Review
Written by Susanne Müller-Knapp and Peter J. Brown, this review gives an overview of the development of chemical probes for epigenetic targets, as well as the impact of these tool compounds being made available to the scientific community. In addition, their biological effects are also discussed. Epigenetic compounds available from Tocris are listed.