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Description: Cell-permeable caspase-9 inhibitor
Chemical Name: Benzyloxycarbonyl-Leu-Glu(OMe)-His-Asp(OMe)-fluoromethylketone
Biological Activity for Z-LEHD-FMK
Cell-permeable inhibitor of caspase-9. Inhibits MG 132-induced cancer cell death and protects isolated rat hearts against ischemia-reperfusion injury. Neuroprotective following cerebral ischemia in rats in vivo.
Technical Data for Z-LEHD-FMK
| M. Wt | 690.72 |
| Formula | C32H43FN6O10 |
| Sequence |
LEHD (Modifications: Leu-1 = Z-Leu, Glu-2 = Glu(OMe), Asp-4 = (OMe)-fluoromethylketone) |
| Storage | Desiccate at -20°C |
| Smiles | [H]N([C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)OC)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CC(=O)OC)C(=O)CF)C(=O)OCC1=CC=CC=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Z-LEHD-FMK
References for Z-LEHD-FMK
References are publications that support the biological activity of the product.
Mocanu et al (2000) Capsase inhibition and limitation of myocardial infarct size: protection against lethal reperfusion injury. Br.J.Pharmacol. 130 197 PMID: 10807653
Mouw et al (2002) Caspase-9 inhibition after focal cerebral ischemia improves outcome following reversible focal ischemia. Metab.Brain Dis. 17 143 PMID: 12322785
Bang et al (2004) Differential response of MG132 cytotoxicity against small cell lung cancer cells to changes in cellular GSH contents. Biochem.Pharmacol. 68 659 PMID: 15276073
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Keywords: Z-LEHD-FMK, Z-LEHD-FMK supplier, Cell-permeable, caspase-9, inhibitors, inhibits, Caspases, Proteinases, Proteases, 2171, Tocris Bioscience
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