Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewZacopride hydrochloride
Description: Highly potent 5-HT3 antagonist; also 5-HT4 agonist
Chemical Name: (±)-4-Amino-N-1-azabicyclo[2.2.2]oct-3-yl-5-chloro-2-methoxybenzamide hydrochloride
Purity: ≥99% (HPLC)
Biological Activity for Zacopride hydrochloride
Zacopride hydrochloride is a highly potent 5-HT3 receptor antagonist (Ki = 0.38 nM) and 5-HT4 receptor agonist (Ki = 373 nM). Antiemetic and anxiolytic following systemic administration in vivo.
Compound Libraries for Zacopride hydrochloride
Zacopride hydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for Zacopride hydrochloride
| M. Wt | 346.26 |
| Formula | C15H20ClN3O2.HCl |
| Storage | Desiccate at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 101303-98-4 |
| PubChem ID | 9928181 |
| InChI Key | ITXVOUSORXSTQH-UHFFFAOYSA-N |
| Smiles | Cl.COC1=C(C=C(Cl)C(N)=C1)C(=O)NC1CN2CCC1CC2 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Zacopride hydrochloride
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 34.63 | 100 | |
| DMSO | 34.62 | 100 |
Preparing Stock Solutions for Zacopride hydrochloride
The following data is based on the product molecular weight 346.26. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.89 mL | 14.44 mL | 28.88 mL |
| 5 mM | 0.58 mL | 2.89 mL | 5.78 mL |
| 10 mM | 0.29 mL | 1.44 mL | 2.89 mL |
| 50 mM | 0.06 mL | 0.29 mL | 0.58 mL |
Molarity Calculator
Molarity Calculator
Calculate the mass, volume, or concentration required for a solution.
Reconstitution Calculator
Reconstitution Calculator
Dilution Calculator
Dilution Calculator
Calculate the dilution required to prepare a stock solution.
Product Datasheets for Zacopride hydrochloride
References for Zacopride hydrochloride
References are publications that support the biological activity of the product.
Cohen et al (1989) Comparison of the 5-HT3 receptor antagonist properties of ICS 205-930, GR38032F and zacopride. J.Pharmacol.Exp.Ther. 248 197 PMID: 2521513
Costall et al (1988) Zacopride: anxiolytic profile in rodent and primate models of anxiety. J.Pharm.Pharmacol. 40 302 PMID: 2900320
Kii and Ito (1997) Effects of 5-HT4-receptor agonists, cisapride, mosapride citrate, and zacopride, on cardiac action potentials in guinea pig isolated papillary muscles. J.Cardiovasc.Pharmacol. 29 670 PMID: 9213211
Nagakura et al (1999) Pharmacological properties of a novel gastrointestinal prokinetic benzamide selective for human 5-HT4 receptor versus human 5-HT3 receptor. Pharmacol.Res. 39 375 PMID: 10328995
If you know of a relevant reference for Zacopride hydrochloride, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: Zacopride hydrochloride, Zacopride hydrochloride supplier, 5-HT4, agonists, potent, 5-HT3, antagonists, Serotonin, Receptors, 5-Hydroxytryptamine, 1795, Tocris Bioscience
3 Citations for Zacopride hydrochloride
Citations are publications that use Tocris products. Selected citations for Zacopride hydrochloride include:
Wang et al (2016) 5-HTR3 and 5-HTR4 located on the mitochondrial membrane and functionally regulated mitochondrialfunctions Scientific Reports 6 37336 PMID: 27874067
Ding et al (2015) The reinforcing effects of ethanol within the nucleus accumbens shell involve activation of local GABA and serotonin receptors. Toxins (Basel) 29 725 PMID: 25922425
Otvos et al (2015) Development of Plate Reader and On-Line Microfluidic Screening to Identify Ligands of the 5-Hydroxytryptamine Binding Protein in Venoms. Circulation 7 2336 PMID: 26114334
Do you know of a great paper that uses Zacopride hydrochloride from Tocris? Please let us know.
Reviews for Zacopride hydrochloride
There are currently no reviews for this product. Be the first to review Zacopride hydrochloride and earn rewards!
Have you used Zacopride hydrochloride?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
5-HT Receptors Scientific Review
Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.