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Submit ReviewPerindopril erbumine
Description: Angiotensin-converting enzyme (ACE) inhibitor
Chemical Name: (2S,3aS,7aS)-1-[(2S)-2-[[(1S)-1-(Ethoxycarbonyl)butyl]amino]-1-oxopropyl]octahydro-1H-indole-2-carboxylic acid tert-butylamine salt
Purity: ≥99% (HPLC)
Biological Activity for Perindopril erbumine
Perindopril erbumine is an angiotensin-converting enzyme (ACE) inhibitor (IC50 = 1.05 nM). Brain penetrant. Suppresses the increase in hippocampal ACE activity and improves cognition in PS2APP-transgenic mice.
Technical Data for Perindopril erbumine
| M. Wt | 441.6 |
| Formula | C19H32N2O5.C4H11N |
| Storage | Store at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 107133-36-8 |
| PubChem ID | 441313 |
| InChI Key | IYNMDWMQHSMDDE-MHXJNQAMSA-N |
| Smiles | C[C@H](N[C@H]([C@@](OCC)=O)CCC)C(N1[C@H]([C@@](O)=O)C[C@@]2([H])[C@@]([H])1CCCC2)=O.NC(C)(C)C |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Perindopril erbumine
References for Perindopril erbumine
References are publications that support the biological activity of the product.
Takai et al (2004) Significant target organs for hypertension and cardiac hypertrophy by angiotensin-converting enzyme inhibitors. Hypertens.Res. 27 213 PMID: 15080380
Ceconi et al (2007) Angiotensin-converting enzyme (ACE) inhibitors have different selectivity for bradykinin binding sites of human somatic ACE. Eur.J.Pharmacol. 577 1 PMID: 17716647
Dong et al (2011) Perindopril, a centrally active angiotensin-converting enzyme inhibitor, prevents cognitive impairment in mouse models of Alzheimer's disease. FASEB J. 25 2911 PMID: 21593435
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Keywords: Perindopril erbumine, Perindopril erbumine supplier, inhibits, angiotensin-converting, enzyme, ACE, inhibitors, Angiotensin-Converting, Enzyme, 4302, Tocris Bioscience
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