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Submit Review740 Y-P
Description: Cell-permeable PI 3-kinase activator
Alternative Names: PDGFR740Y-P
Purity: ≥85% (HPLC)
Biological Activity for 740 Y-P
740 Y-P is a cell-permeable phosphopeptide activator of PI 3-kinase. Binds with high affinity to p85 subunit of the enzyme. Displays mitogenic activity in C2 muscle cells and promotes survival of rat cerebellar granule neurons in vitro.
Technical Data for 740 Y-P
| M. Wt | 3270.72 |
| Formula | C141H222N43O39PS3 |
| Sequence |
RQIKIWFQNRRMKWKKSDGGYMDMS (Modifications: Tyr-21 = pTyr) |
| Storage | Store at -20°C |
| Purity | ≥85% (HPLC) |
| CAS Number | 1236188-16-1 |
| PubChem ID | 90488730 |
| InChI Key | XCGMILZGRGEWHL-QYGSNONCSA-N |
| Smiles | [H]N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(O)=O)C(=O)NCC(=O)NCC(=O)N[C@@H](CC1=CC=C(OP(O)(O)=O)C=C1)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CO)C(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for 740 Y-P
| Solubility | Soluble to 1 mg/ml in water |
Product Datasheets for 740 Y-P
References for 740 Y-P
References are publications that support the biological activity of the product.
Williams and Doherty (1999) Evidence for and against a pivotal role of PI 3-kinase in a neuronal cell survival pathway. Mol.Cell.Neurosci. 13 272 PMID: 10328886
Derossi et al (1998) Stimulation of mitogenesis by a cell-permeable PI 3-kinase binding peptide. Biochem.Biophys.Res.Comm. 251 148
If you know of a relevant reference for 740 Y-P, please let us know.
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Keywords: 740 Y-P, 740 Y-P supplier, Cell-permeable, PI, 3-kinase, activators, PI3K, 740YP, phosphopeptide, activator, p85, PDGFR740Y-P, 3-Kinase, Inositol, Lipids, Enzyme, Substrates, /, Activators, 1983, Tocris Bioscience
10 Citations for 740 Y-P
Citations are publications that use Tocris products. Selected citations for 740 Y-P include:
Sun et al (2015) New strategy for in vitro activation of primordial follicles with mTOR and PI3K stimulators. Cell Cycle 14 721 PMID: 25590233
Lerer-Serfaty et al (2013) Attempted application of bioengineered/biosynthetic supporting matrices with phosphatidylinositol-trisphosphate-enhancing substances to organ culture of human primordial follicles. Proc Natl Acad Sci U S A 30 1279 PMID: 23934019
Dolmans et al (2019) In vitro Activation Prior to Transplantation of Human Ovarian Tissue: Is It Truly Effective? Front Endocrinol (Lausanne) 10 520 PMID: 31428051
Lomakin et al (2015) Competition for actin between two distinct F-actin networks defines a bistable switch for cell polarization. Nat Cell Biol 17 1435 PMID: 26414403
Grassin-Delyle et al (2013) The expression and relaxant effect of bitter taste receptors in human bronchi. Respir Res 14 134 PMID: 24266887
Jia et al (2013) Age-dependent regulation of synaptic connections by DA D2 receptors. Nat Neurosci 16 1627 PMID: 24121738
Hong et al (2012) Apoptosis resistance and PKC signaling: distinguishing features of high and low metastatic cells. Neoplasia 14 249 PMID: 22496624
Sun et al (2015) Thyroid hormone inhibits the proliferation of piglet Sertoli cell via PI3K signaling pathway. J Assist Reprod Genet 83 86 PMID: 25284282
Li et al (2010) Activation of dormant ovarian follicles to generate mature eggs. Nat Commun 107 10280 PMID: 20479243
Drelich et al (2018) Exchange Protein Directly Activated by cAMP Modulates Ebola Virus Uptake into Vascular Endothelial Cells. Viruses 10 PMID: 30332733
Do you know of a great paper that uses 740 Y-P from Tocris? Please let us know.
Reviews for 740 Y-P
Average Rating: 3 (Based on 1 Review.)
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in vitro PI3K activation.
By
Anonymous on 07/12/2018
Assay Type: In Vitro
Species: Human
Cell Line/Tissue: MCF10A
Added in culture medium to promote PI3K pathway
Not sure if it is working or notWish larger amounts with discount were available