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CRF2 Receptors

The corticotropin-releasing factor (CRF) 2 receptor is a member of the corticotropin-releasing factor family of G-protein-coupled receptors that also includes CRF1. Three functional splice variants have been identified for the mammalian CRF2 receptor; CRF2a, CRF2b and CRF2c.

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Gene Data

CRF2 Receptor Antagonists
Cat. No. 产品名称/活性
2391 Astressin 2B
Selective CRF2 antagonist
2070 K 41498
Highly selective and potent CRF2 antagonist

Related Targets

    The corticotropin-releasing factor (CRF) 2 receptor is a member of the corticotropin-releasing factor family of G-protein-coupled receptors that also includes CRF1. Three functional splice variants have been identified for the mammalian CRF2 receptor; CRF2a, CRF2b and CRF2c. All three splice variants display different tissue distribution but the pharmacological and biological properties remain unchanged.

    The physiological functions of CRF2 receptors are currently unclear but activation of these receptors is known to induce anxiety and hypersensitivity to stress, and increase glucagon and insulin secretion from islet cells. The human gene encoding the CRF2 receptor is localized on chromosome 17 (17q12-q22).

    External sources of pharmacological information for CRF2 Receptors :

    Literature for CRF2 Receptors

    Tocris offers the following scientific literature for CRF2 Receptors to showcase our products. We invite you to request* your copy today!

    *Please note that Tocris will only send literature to established scientific business / institute addresses.

    Depression Poster

    Depression Poster

    Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.

    CRF2 Receptor Gene Data

    Species Gene Symbol Gene Accession No. Protein Accession No.
    Human CRHR2 NM_001883 Q13324
    Mouse Crhr2 NM_009953 Q60748
    Rat Crhr2 NM_022714 P47866