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Submit Review2-[1-(4-Piperonyl)piperazinyl]benzothiazole
说明： 5-HT4 agonist; also 5-HT3 antagonist
生物活性
5-HT4 receptor agonist with moderate activity as a 5-HT3 antagonist. Has no affinity at 5-HT1 or dopamine D2 receptors. Potential gastrokinetic agent.
技术数据
| 分子量 | 353.44 |
| 公式 | C19H19N3O2S |
| 储存 | Store at RT |
| CAS Number | 155106-73-3 |
| PubChem ID | 127902 |
| InChI Key | BYHKGNWKJMGHGE-UHFFFAOYSA-N |
| Smiles | C(N1CCN(CC1)C1=NC2=CC=CC=C2S1)C1=CC2=C(OCO2)C=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书
分析证书目前不在网上提供。
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参考文献
参考文献是支持产品生物活性的出版物。
Monge et al (1994) Synthesis of 2-piperazinybenzothiazole and 2-piperazinylbenzoxazole derivatives with 5-HT3 antagonist and 5-HT4 agonist properties. J.Med.Chem. 37 1320 PMID: 8176710
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关键词: 2-[1-(4-Piperonyl)piperazinyl]benzothiazole, 2-[1-(4-Piperonyl)piperazinyl]benzothiazole supplier, 5-HT4, agonists, 5-HT3, antagonists, Serotonin, Receptors, 5-Hydroxytryptamine, 5-HT, 0736, Tocris Bioscience
1 篇 2-[1-(4-Piperonyl)piperazinyl]benzothiazole 的引用文献
引用文献是使用了 Tocris 产品的出版物。 2-[1-(4-Piperonyl)piperazinyl]benzothiazole 的部分引用包括：
Gill et al (2008) Serotonin modifies cytoskeleton and brush-border membrane architecture in human intestinal epithelial cells. Am J Physiol Gastrointest Liver Physiol 295 G700 PMID: 18669621
2-[1-(4-Piperonyl)piperazinyl]benzothiazole 的评论
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
5-HT Receptors Scientific Review
Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.
Depression Poster
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.