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4-Octyl itaconate

Cat. No. 6662 2 篇引用文献 1 条评论 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Nrf2 activator; cell permeable
化学名： 2-Methylenebutanedioic acid 4-octyl ester
纯度： ≥98% (HPLC)
说明书
引用文献 (2)
评论 (1)
文献 (2)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for 4-Octyl itaconate

4-Octyl itaconate activates Nrf2. Inhibits LPS-induced increases in IL-1β mRNA, HIF-1α and IL-10 in macrophages. Decreases cytokine production in response to LPS in mice and prolongs survival. Cell permeable.

化合物库 for 4-Octyl itaconate

4-Octyl itaconate is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for 4-Octyl itaconate

分子量 242.31
公式 C13H22O4
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 3133-16-2
PubChem ID 14239884
InChI Key KBASUIDPDITQHT-UHFFFAOYSA-N
Smiles CCCCCCCCOC(CC(C(O)=O)=C)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for 4-Octyl itaconate

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 24.23 100

制备储备液 for 4-Octyl itaconate

以下数据基于产品分子量 242.31。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 4.13 mL 20.63 mL 41.27 mL
5 mM 0.83 mL 4.13 mL 8.25 mL
10 mM 0.41 mL 2.06 mL 4.13 mL
50 mM 0.08 mL 0.41 mL 0.83 mL

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产品说明书 for 4-Octyl itaconate

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for 4-Octyl itaconate

参考文献是支持产品生物活性的出版物。

Mills et al (2018) Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1. Nature 556 113 PMID: 29590092

If you know of a relevant reference for 4-Octyl itaconate, please let us know.

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关键词: 4-Octyl itaconate, 4-Octyl itaconate supplier, anti-inflammatory, Nrf2, activators, activates, cell, permeable, 6662, Tocris Bioscience

2 篇 4-Octyl itaconate 的引用文献

引用文献是使用了 Tocris 产品的出版物。 4-Octyl itaconate 的部分引用包括：

Matthew A et al (2022) Itaconate and Its Derivatives Repress Early Myogenesis In Vitro and In Vivo. Front Immunol 13 748375 PMID: 35265064

Yang et al (2020) Itaconate prevents abdominal aortic aneurysm formation through inhibiting inflammation via activation of Nrf2. EBioMedicine 57 102832 PMID: 32574955

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4-Octyl itaconate 的评论

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Good product.
By Rabina Mainali on 09/22/2022
分析类型： In Vitro
种属： Mouse
细胞系/组织： C2C12

In vitro treatment of C2C12 cells. The image shows the effects of dimethyl itaconate (DMI) and 4-Octyl itaconate (4-OI) on myogenesis

参考文献
review image

该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。

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