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6-Hydroxy-DL-DOPA

Cat. No. 5740 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Allosteric inhibitor of RAD52; also APE1 inhibitor
化学名： 2,5-Dihydroxy-DL-tyrosine
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引用文献
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生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for 6-Hydroxy-DL-DOPA

6-Hydroxy-DL-DOPA is an allosteric inhibitor of RAD52; inhibits RAD52 binding to single strand DNA binding domains (IC50 = 1.1 μM). Selectively inhibits proliferation of BRCA-deficient cancer cells in vitro. Also inhibits APE1.

技术数据 for 6-Hydroxy-DL-DOPA

分子量 213.19
公式 C9H11NO5
储存 Store at -20°C
CAS Number 21373-30-8
PubChem ID 107794
InChI Key YLKRUSPZOTYMAT-UHFFFAOYSA-N
Smiles OC1=C(O)C=C(O)C(CC(C(O)=O)N)=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for 6-Hydroxy-DL-DOPA

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
1M HCl 21.32 100

制备储备液 for 6-Hydroxy-DL-DOPA

以下数据基于产品分子量 213.19。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 4.69 mL 23.45 mL 46.91 mL
5 mM 0.94 mL 4.69 mL 9.38 mL
10 mM 0.47 mL 2.35 mL 4.69 mL
50 mM 0.09 mL 0.47 mL 0.94 mL

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产品说明书 for 6-Hydroxy-DL-DOPA

分析证书/产品说明书
化学品安全技术说明书

参考文献 for 6-Hydroxy-DL-DOPA

参考文献是支持产品生物活性的出版物。

Wilson DM 3rd et al (2010) Small molecule inhibitors of DNA repair nuclease activities of APE1. Cell Mol.Life Sci. 67 3621 PMID: 20809131

Simeonov et al (2009) Identification and characterization of inhibitors of human apurinic/apyrimidinic endonuclease APE1. PLoS One 4 e5740 PMID: 19484131

Chandramouly et al (2015) Small-Molecule Disruption of RAD52 Rings as a Mechanism for Precision Medicine in BRCA-Deficient Cancers. Chem.Biol. 22 1491 PMID: 26548611

If you know of a relevant reference for 6-Hydroxy-DL-DOPA, please let us know.

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关键词: 6-Hydroxy-DL-DOPA, 6-Hydroxy-DL-DOPA supplier, Allosteric, inhibitors, RAD52, APE1, BRCA, deficient, cancer, synthetic, lethality, inhibits, DNA,, RNA, and, Protein, Synthesis, 5740, Tocris Bioscience

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