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6-Hydroxy-DL-DOPA

Cat. No. 5740 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

5740 has been discontinued.

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说明： Allosteric inhibitor of RAD52; also APE1 inhibitor
化学名： 2,5-Dihydroxy-DL-tyrosine
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生物活性 技术数据 说明书 参考文献

生物活性 for 6-Hydroxy-DL-DOPA

6-Hydroxy-DL-DOPA is an allosteric inhibitor of RAD52; inhibits RAD52 binding to single strand DNA binding domains (IC50 = 1.1 μM). Selectively inhibits proliferation of BRCA-deficient cancer cells in vitro. Also inhibits APE1.

技术数据 for 6-Hydroxy-DL-DOPA

分子量 213.19
公式 C9H11NO5
储存 Store at -20°C
CAS Number 21373-30-8
PubChem ID 107794
InChI Key YLKRUSPZOTYMAT-UHFFFAOYSA-N
Smiles OC1=C(O)C=C(O)C(CC(C(O)=O)N)=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for 6-Hydroxy-DL-DOPA

分析证书/产品说明书
化学品安全技术说明书

参考文献 for 6-Hydroxy-DL-DOPA

参考文献是支持产品生物活性的出版物。

Wilson DM 3rd et al (2010) Small molecule inhibitors of DNA repair nuclease activities of APE1. Cell Mol.Life Sci. 67 3621 PMID: 20809131

Simeonov et al (2009) Identification and characterization of inhibitors of human apurinic/apyrimidinic endonuclease APE1. PLoS One 4 e5740 PMID: 19484131

Chandramouly et al (2015) Small-Molecule Disruption of RAD52 Rings as a Mechanism for Precision Medicine in BRCA-Deficient Cancers. Chem.Biol. 22 1491 PMID: 26548611

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关键词: 6-Hydroxy-DL-DOPA, 6-Hydroxy-DL-DOPA supplier, Allosteric, inhibitors, RAD52, APE1, BRCA, deficient, cancer, synthetic, lethality, inhibits, DNA,, RNA, and, Protein, Synthesis, 5740, Tocris Bioscience

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