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6-Mercaptopurine

Cat. No. 4103 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

4103 has been discontinued.

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说明： Purine analog; inhibits DNA and RNA synthesis
化学名： Purine-6(1H)-thione
纯度： ≥99% (HPLC)
说明书
引用文献 (1)
评论
文献 (2)
生物活性 技术数据 说明书 参考文献

生物活性 for 6-Mercaptopurine

6-Mercaptopurine is an inhibitor of de novo purine synthesis through interference with DNA and RNA synthesis. Immunosuppressive and antileukemic drug; reduces the anticoagulation elicited by warfarin. Active metabolite of azathioprine (Cat. No. 4099). Also inhibits SARS-CoV papain-like protease (PLpro; IC50 = 21.6 μM for PLpro deubiquitination activity).

技术数据 for 6-Mercaptopurine

分子量 152.18
公式 C5H4N4S
储存 Store at RT
纯度 ≥99% (HPLC)
CAS Number 50-44-2
PubChem ID 3000241
InChI Key GLYGRBPLZURLDD-UHFFFAOYSA-N
Smiles S=C1C2C(N=CN2)N=CN1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for 6-Mercaptopurine

分析证书/产品说明书
化学品安全技术说明书

参考文献 for 6-Mercaptopurine

参考文献是支持产品生物活性的出版物。

Sahasranaman et al (2008) Clinical pharmacology and pharmacogenetics of thiopurines. Eur.J.Clin.Pharmacol. 64 753 PMID: 18506437

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关键词: 6-Mercaptopurine, 6-Mercaptopurine supplier, 6-Mercaptopurine, thiopurine, immunosuppressant, drug, 6-MP, purine, analog, chemotherapeutics, DNA,, RNA, and, Protein, Synthesis, Immunosuppressants, Papain-like, Proteases, 4103, Tocris Bioscience

1 篇 6-Mercaptopurine 的引用文献

引用文献是使用了 Tocris 产品的出版物。 6-Mercaptopurine 的部分引用包括：

Ari et al (2021) Combined epigenetic and metabolic treatments overcome differentiation blockade in acute myeloid leukemia. iScience 24 102651 PMID: 34151238

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