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Submit Review8-Bromo-cAMP, sodium salt
说明： Cell-permeable cAMP analog
化学名： 8-Bromoadenosine-3',5'-cyclic monophosphate sodium salt
纯度： ≥99% (HPLC)
生物活性 for 8-Bromo-cAMP, sodium salt
8-Bromo-cAMP, sodium salt is a cell-permeable cyclic AMP (cAMP) analog. It activates PKA and has greater resistance to hydrolysis by phosphodiesterase (PDE) than cAMP. It increases differentiation and induces apoptosis in an esophageal cancer cell line. 8-Bromo-cAMP enhances the induction of pluripotency in human fibroblast cells in combination with VPA (valproic acid) (Cat. No. 2815). In combination with IBMX (Cat. No. 2845), it promotes the differentiation of human iPS cell-derived intestinal epithelial cells. It induces cell-based VEGF production for angiogenesis and osteoblastic differentiation in vitro.
化合物库 for 8-Bromo-cAMP, sodium salt
8-Bromo-cAMP, sodium salt is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Epigenetics Library and Tocriscreen Stem Cell Library. 了解 Tocris 化合物库的更多信息。
技术数据 for 8-Bromo-cAMP, sodium salt
| 分子量 | 430.09 |
| 公式 | C10H10BrN5NaO6P |
| 储存 | Store at -20°C |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 76939-46-3 |
| PubChem ID | 23702958 |
| InChI Key | DMRMZQATXPQOTP-GWTDSMLYSA-M |
| Smiles | [Na+].[H][C@@]12COP([O-])(=O)O[C@@]1([H])[C@@H](O)[C@@H](O2)N1C(Br)=NC2=C1N=CN=C2N |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for 8-Bromo-cAMP, sodium salt
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| water | 43.01 | 100 | |
| DMSO | 43.01 | 100 |
制备储备液 for 8-Bromo-cAMP, sodium salt
以下数据基于产品分子量 430.09。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.33 mL | 11.63 mL | 23.25 mL |
| 5 mM | 0.47 mL | 2.33 mL | 4.65 mL |
| 10 mM | 0.23 mL | 1.16 mL | 2.33 mL |
| 50 mM | 0.05 mL | 0.23 mL | 0.47 mL |
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产品说明书 for 8-Bromo-cAMP, sodium salt
参考文献 for 8-Bromo-cAMP, sodium salt
参考文献是支持产品生物活性的出版物。
Carranza et al (1998) Protein kinase A induces recruitment of active Na+,K+-ATPase units to the plasma membrane of rat proximal convoluted tubule cells. J.Physiol. 511 235 PMID: 9679177
Chow et al (1998) Functional modulation of P2X2 receptors by cyclic AMP-dependent protein kinase. J.Neurochem. 70 2606 PMID: 9603227
Hei et al (1991) Lack of correlation between activation of cyclic AMP-dependent protein kinase and inhibition of contraction of rat vas deferens by cyclic AMP analogs. Mol.Pharmacol. 39 233 PMID: 1847496
Wang et al (2011) A cyclic AMP analog, 8-Br-cAMP, enhances the induction of pluripotency in human fibroblast cells. Stem Cell Rev. 7 331 PMID: 21120637
Wang et al (2005) Dual effects of 8-Br-cAMP on differentiation and apoptosis of human esophageal cancer cell line Eca-109. World J.Gastroenterol. 11 6538 PMID: 16425431
Lo et al (2016) One-day treatment of small molecule 8-bromo-cyclic AMP analogue induces cell-based VEGF production for in vitro angiogenesis and osteoblastic differentiation. J.Tissue.Eng.Regen. Med. 10 867 PMID: 24493289
If you know of a relevant reference for 8-Bromo-cAMP, sodium salt, please let us know.
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关键词: 8-Bromo-cAMP, sodium salt, 8-Bromo-cAMP, sodium salt supplier, Cell-permeable, cAMP, Membrane, permeable, analog, activates, activators, PKA, Cyclic, adenosines, Monophosphate, Inositol, Signaling, Signalling, Protein, Kinase, A, Kinases, apoptosis, reprogramming, angiogenesis, osteoblastic, differentiation, Other, Apoptosis, ESCs, and, iPSC, 1140, Tocris Bioscience
8 篇 8-Bromo-cAMP, sodium salt 的引用文献
引用文献是使用了 Tocris 产品的出版物。 8-Bromo-cAMP, sodium salt 的部分引用包括：
Sergeant et al (2009) Spontaneous Ca2+ waves in rabbit corpus cavernosum: modulation by nitric oxide and cGMP. J.Sex.Med. 6 958 PMID: 19138373
Tuesta (2017) GLP-1 acts on habenular avoidance circuits to control nicotine intake. Nat Neurosci 20 708 PMID: 28368384
Wang et al (2015) Astaxanthin protects steroidogenesis from hydrogen peroxide-induced oxidative stress in mouse Leydig cells. J Neurosci 13 1375 PMID: 25786065
Nakao et al (2012) The role of mislocalized phototransduction in photoreceptor cell death of retinitis pigmentosa. PLoS One 7 e32472 PMID: 22485131
Goffin et al (2010) DA-dependent tuning of striatal inhibitory synaptogenesis. Br J Pharmacol 30 2935 PMID: 20181591
Tozzi et al (2015) Endogenous 17β-OE is required for activity-dependent long-term potentiation in the striatum: interaction with the DArgic system. Front Cell Neurosci 9 192 PMID: 26074768
Adelfinger et al (2014) GABAB receptor phosphorylation regulates KCTD12-induced K+ current desensitization. Biochem Pharmacol 91 369 PMID: 25065880
Niedenberger et al (2014) Actin dynamics regulate subcellular localization of PALLD in mouse Sertoli cells. Reproduction PMID: 24989903
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8-bromo-cAMP phosphorylates cardiac CaMKII.
By
Anonymous on 05/15/2019
分析类型： In Vitro
种属： Mouse
细胞系/组织： Cardiomyocytes
HL-1 cardiomyocytes were treated with 100 nM fostriecin, 100 nM Okadaic acid or 50 nM 8-bromo-cAMP for 30 min followed by Western blot analysis for pCaMKII expression. 8-bromo-cAMP increased phosphorylation of CaMKII; indicating role of cAMP in CaMKII dephosphorylation.
