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8-Chloroadenosine

Cat. No. 4436 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Cytotoxic nucleoside analog; inhibits RNA synthesis
化学名： 6-Amino-8-chloropurine riboside
纯度： ≥98% (HPLC)
说明书
引用文献 (1)
评论
文献 (2)
生物活性 技术数据 说明书 参考文献

生物活性 for 8-Chloroadenosine

8-Chloroadenosine is a nucleoside analog; metabolized in vivo to 8-Chloro-ATP. Incorporates into RNA during transcription and inhibits RNA synthesis. Exhibits cytotoxicity in MM.1S, RPMI-8226 and U266 cancer cell lines; induces G2/M cell cycle arrest and mitotic catastrophe in A549 and H1299 cells.

技术数据 for 8-Chloroadenosine

分子量 301.69
公式 C10H12ClN5O4
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 34408-14-5
PubChem ID 90488943
InChI Key MHDPPLULTMGBSI-LZGMGDPASA-N
Smiles O[C@@H]1[C@@H](CO)OC(N3C2=NC=NC(N)=C2N=C3Cl)[C@@H]1O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for 8-Chloroadenosine

分析证书/产品说明书
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化学品安全技术说明书

参考文献 for 8-Chloroadenosine

参考文献是支持产品生物活性的出版物。

Zhang et al (2004) Exposure of human lung cancer cells to 8-chloro-adenosine induces G2/M arrest and mitotic catastrophe. Neoplasia 6 802 PMID: 15720807

Gu et al (2006) 8-Chloro-adenosine inhibits growth at least partly by interfering with actin polymerization in cultured human lung cancer cells Biochem.Pharmacol. 72 541 PMID: 16844099

Cervantes-Gomez et al (2011) ATP analog enhances the actions of a heat shock protein 90 inhibitor in multiple myeloma cells. J.Pharmacol.Exp.Ther. 339 545 PMID: 21821695

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关键词: 8-Chloroadenosine, 8-Chloroadenosine supplier, 8-Cl-Ado, 8-Cl-ATP, cytotoxic, chemotherapeutics, growth, arrest, RNA, synthesis, transcription, inhibitors, inhibits, nucleoside, analogs, DNA,, and, Protein, Synthesis, Cell, Cycle, Inhibitors, 4436, Tocris Bioscience

1 篇 8-Chloroadenosine 的引用文献

引用文献是使用了 Tocris 产品的出版物。 8-Chloroadenosine 的部分引用包括：

Kearney et al (2015) 8-Chloroadenosine Sensitivity in Renal Cell Carcinoma Is Associated with AMPK Activation and mTOR Pathway Inhibition. PLoS One 10 e0135962 PMID: 26313261

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